The mTOR pathway: Implications for DNA replication

Publication date: Available online 13 April 2019Source: Progress in Biophysics and Molecular BiologyAuthor(s): Noa Lamm, Samuel Rogers, Anthony J. CesareAbstractDNA replication plays a central role in genome health. Deleterious alteration of replication dynamics, or “replication stress”, is a key driver of genome instability and oncogenesis. The replication stress response is regulated by the ATR kinase, which functions to mitigate replication abnormalities through coordinated efforts that arrest the cell cycle and repair damaged replication forks. mTOR kinase regulates signaling networks that control cell growth and metabolism in response to environmental cues and cell stress. In this review, we discuss interconnectivity between the ATR and mTOR pathways, and provide putative mechanisms for mTOR engagement in DNA replication and the replication stress response. Finally, we describe how connectivity between mTOR and replication stress may be exploited for cancer therapy.
Source: Progress in Biophysics and Molecular Biology - Category: Molecular Biology Source Type: research