Lipolysis Defect in White Adipose Tissue and Rapid Weight Regain.

Lipolysis Defect in White Adipose Tissue and Rapid Weight Regain. Am J Physiol Endocrinol Metab. 2019 Apr 09;: Authors: Kasher-Meron M, Youn DY, Zong H, Pessin JE Abstract Weight regain after weight loss is a well described-phenomena in both humans and animal models of obesity. Reduced energy expenditure and increased caloric intake are considered the main drivers of weight regain. We hypothesized that adipose tissue with obesity memory (OM), has a tissue-autonomous lipolytic defect allowing increased efficiency of lipid storage. We utilized a mouse model of diet induced obesity, which was subjected to 60% caloric restriction to achieve lean body weight, followed by a short period of high fat diet (HFD) re-challenge. Age-matched lean mice fed HFD for the first time were used as control group. Upon re-challenge with HFD mice with OM had higher respiratory exchange ratio than lean mice with no OM, despite comparable body weight, suggesting higher utilization of glucose over fatty acid oxidation. White adipose tissue explants with OM had comparable lipolytic response after caloric restriction, however reduced functional lipolytic response to norepinephrine was noted as early as 5 days after re-challenge with HFD and was accompanied by reduction in HSL serine phosphorylation. The relative lipolytic defect was associated with increased expression of inflammatory genes, and a decrease in adrenergic receptors genes, most notably Adrb3. Take...
Source: American Journal of Physiology. Endocrinology and Metabolism - Category: Physiology Authors: Tags: Am J Physiol Endocrinol Metab Source Type: research