Facile Fabrication of pH-responsive Nanoparticles from Cellulose Derivatives via Schiff base formation for Controlled Release

This study demonstrates the formation of a group of novel pH-sensitive and drug-loadable NPs, which provide a simple and efficient drug delivery system for the potential application for cancer treatment.Graphical abstractNovel pH-responsive nanoparticles as promising delivery system were designed and constructed using 2,3-dialdehyde cellulose derivatives. The resulting nanoparticles showed adjustable loading capacity that was tuned by changing the ratio of oleylamine and amino-containing compounds. The loaded nanoparticles exhibited excellent pH-regulated release behaviors via the cleavage of Schiff base bonds in aqueous environment with various pH values.
Source: Carbohydrate Polymers - Category: Biomedical Science Source Type: research