UConn and Foundation for Prader Willi Research create stem cell biobank

(University of Connecticut) A new collaboration between UConn Health and the Foundation for Prader-Willi Research will create a centralized, high quality biobank of stem cells to help researchers better understand Prader-Willi syndrome, a rare genetic disease that may hold insights into obesity, developmental delays, autism spectrum disorders, and many other conditions.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

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Publication date: Available online 14 October 2019Source: Biochemical Engineering JournalAuthor(s): Jinfeng Li, Guowei Shang, Yisheng Wang, Xiuli Wang, Yuanyuan Ji, Yuebai LiAbstractCalcitonin gene-related peptide (CGRP) promotes proliferation and osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs), which influence bone regeneration and reconstruction. We previously established CGRP-modified BMSCs that express the CGRP gene and demonstrated that this elevated CGRP expression promotes osteogenic differentiation of BMSCs. The current study investigated the therapeutic effects of CGRP-modified BMSCs combi...
Source: Biochemical Engineering Journal - Category: Biochemistry Source Type: research
The objectives of this study were to examine the trends in intersection density in the US from 2007 to 2011 and assess the associations between intersection density and childho...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
ConclusionsThe study demonstrated that the FHIR-based EHR phenotyping approach could effectively identify the state of obesity and multiple comorbidities using semi-structured discharge summaries. Our FHIR-based phenotyping approach is a first concrete step towards improving the data aspect of phenotyping portability across EHR systems and enhancing interpretability of the machine learning-based phenotyping algorithms.Graphical abstract
Source: Journal of Biomedical Informatics - Category: Information Technology Source Type: research
B cells are important to the coordination of the immune response. Dysfunctional B cells emerge with age, however, leading to autoimmunity and contributing to immunosenescence, the name given to the general age-related decline in effectiveness of the immune system. Animal studies have shown that selective destruction of the entire B cell population is beneficial in older individuals, improving the immune response: the cells are quickly replaced, but the harmful portion will take much longer to reemerge. Setting all of this to one side, the open access review here is largely focused on more subtle changes in the B cell popul...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
The ability of resting-state functional MRI (fMRI) to pinpoint reduced brain...Read more on AuntMinnie.comRelated Reading: fMRI connects words to brain activity fMRI may speed up diagnosis of autism fMRI links imaging biomarker to PTSD treatment response PET, fMRI shed light on alcohol's effects on brain Machine learning, fMRI unlock cellular brain properties
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
Publication date: Available online 12 October 2019Source: Journal of Bioscience and BioengineeringAuthor(s): Kiyomi Yoda, Yoshitsugu Ohnuki, Shinji Masui, Hiroshi KurosawaWe optimized the conditions for the differentiation of human induced pluripotent stem cells (hiPSCs) into mesoderm lineage-committed cells by supplementing the cultures with CHIR, a selective GSK-3 inhibitor, during embryoid body (EB) formation. In vitro treatment with 4 μM CHIR during the late 2 days of a 4-day suspension culture period was most effective at promoting mesodermal differentiation. The resulting EBs showed a significant increas...
Source: Journal of Bioscience and Bioengineering - Category: Biomedical Science Source Type: research
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - Category: Endocrinology Tags: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Source Type: research
Abstract Challenging behaviors involving food are common for individuals with Prader-Willi syndrome (PWS) and often lead to obesity and other chronic health conditions. Efforts to decrease these behaviors, such as isolation during meals and strict monitoring of food consumption, can be stigmatizing. To decrease the food stealing of a 7 year-old girl with PWS, therapists conducted a latency-based functional analysis in a clinic setting before implementing a function-based intervention to facilitate her inclusion at the family dinner table. Intervention components entailed differential reinforcement procedures ...
Source: Journal of Autism and Developmental Disorders - Category: Psychiatry Authors: Tags: J Autism Dev Disord Source Type: research
Raising twin boys is a challenge for any single mom, but it’s especially difficult for one particular mom in New Haven, Connecticut. Dianna Schatzlein-Ahern’s two youngest sons, Stevie and Eddie Ahern, are 11. They both suffer from Prader-Willi syndrome, a genetic condition that makes them insatiably hungry no matter how much they eat. “I have to keep everything locked away so they don’t get up in the middle of the night and have a feast,” Schatzlein-Ahern told Barcroft TV. “They can never feel full, so could potentially eat themselves to death.” For health reasons, she a...
Source: Science - The Huffington Post - Category: Science Source Type: news
Publication date: Available online 16 March 2016 Source:Neuropsychologia Author(s): Juliette Salles, Kuzma Strelnikov, Mantoulan Carine, Thuilleaux Denise, Virginie Laurier, Catherine Molinas, Maïthé Tauber, Pascal Barone Prader-Willi syndrome (PWS) is a rare neurodevelopmental and genetic disorder that is characterized by various expression of endocrine, cognitive and behavioral problems, among which a true obsession for food and a deficit of satiety that leads to hyperphagia and severe obesity. Neuropsychological studies have reported that PWS display altered social interactions with a specific weak...
Source: Neuropsychologia - Category: Neurology Source Type: research
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