Hypoxia protects against the cell death triggered by oxovanadium-galactomannan complexes in HepG2 cells.

Conclusion: Although this study is a proof-of-concept of the impact of hypoxia on the potential of polysaccharides, further study is encouraged. The anti-tumor activity of polysaccharides could be achieved in normoxia or through raising the activity of the immune system. In addition, combination strategies for therapy with anti-autophagic drugs could be proposed.
PMID: 30949212 [PubMed - in process]

Source: Cellular and Molecular Biology Letters - April 7, 2019 Category: Biochemistry Authors: Meyenberg Cunha-de Padua M, Noleto GR, de Oliveira Petkowicz CL, Cadena SMSC, Bost F, Pouysségur J, Mazure NM Tags: Cell Mol Biol Lett Source Type: research