Levels of circulating insulin cell-free DNA in women with polycystic ovary syndrome - a longitudinal cohort study.
CONCLUSION: The circulating level of unmethylated and methylated INScfDNA is similar between PCOS and Controls and cannot be used to predict islet β-cell loss and progression to Type 2 diabetes in a 6-year follow-up.
TRIAL REGISTRATION: The Danish Data Protection Agency (REG-31-2016. Approval: 01-12-2015) and by the Danish Scientific Ethical committee of Region Zealand (Journal no. SJ-525. Approval: 13-06-2016), Clinicaltrials.gov, ( NCT03142633 , registered 1. March, 2017, Retrospectively registered).
PMID: 30953560 [PubMed - in process]
Source: Reproductive Biology - Category: Reproduction Medicine Authors: Udesen PB, Sørensen AE, Joglekar MV, Hardikar AA, Wissing MLM, Englund AM, Dalgaard LT Tags: Reprod Biol Endocrinol Source Type: research
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