Early T-cell precursor acute lymphoblastic leukemia with KRAS and DNMT3A mutations and unexpected monosomy 7.

We report a case of ETP-ALL with KRAS and DNMT3A mutations and monosomy of chromosome 7 that did not initially respond to conventional ALL therapy but eventually responded to acute myeloid leukemia-type therapy, underscoring the interesting characteristics of this leukemia. Little information is available regarding monosomy 7 in this entity for the adult population. PMID: 30948995 [PubMed]

https://www.ncbi.nlm.nih.gov/pubmed/30948995?dopt=Abstract

Source: Baylor University Medical Center Proceedings - September 30, 2018 Category: Universities & Medical Training Authors: Tran T, Krause J Tags: Proc (Bayl Univ Med Cent) Source Type: research