National Institutes Of Health Begin Human Trial Of ‘ Universal ’ Flu Vaccine

BOSTON (CBS) – Four children have died from the flu in Massachusetts so far this season, a stark reminder of why it’s so important to get vaccinated every year. Now, the National Institutes of Health has begun the first human trial of a “universal” flu vaccine. This novel flu vaccine was designed to provide long-lasting protection for all age groups against multiple influenza subtypes, including seasonal flu viruses and those that can cause deadly pandemics. This first study is a Phase 1 trial which will look at the vaccine’s safety and side effects, as well as how robustly it stimulates the immune system in humans. They hope to report the results of this trial early next year.
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Boston News Health Healthwatch Syndicated Local Dr. Mallika Marshall Flu Vaccine Source Type: news

Related Links:

Background: A/H5N1 influenza virus has significant pandemic potential, and vaccination is the main prophylactic measure. This phase 2, randomized, observer-blind, multicenter study evaluated the safety and immunogenicity of two MF59-adjuvanted, cell culture-derived H5N1 (aH5N1c) vaccine formulations in healthy pediatric subjects 6 months to 17 years old. Methods: Subjects (N = 662) received 2 aH5N1c doses 3 weeks apart, containing either 7.5 μg (full dose) or 3.75 μg (half dose) hemagglutinin antigen per dose. Local reactions and adverse events (AEs) were assessed by age. Antibody responses were measured by hema...
Source: The Pediatric Infectious Disease Journal - Category: Infectious Diseases Tags: Vaccine Reports Source Type: research
Publication date: Available online 12 June 2019Source: EpidemicsAuthor(s): Timothy C. Germann, Hongjiang Gao, Manoj Gambhir, Andrew Plummer, Matthew Biggerstaff, Carrie Reed, Amra UzicaninAbstractWe used individual-based computer simulation models at community, regional and national levels to evaluate the likely impact of coordinated pre-emptive school dismissal policies during an influenza pandemic. Such policies involve three key decisions: when, over what geographical scale, and how long to keep schools closed. Our evaluation includes uncertainty and sensitivity analyses, as well as model output uncertainties arising fr...
Source: Epidemics - Category: Epidemiology Source Type: research
In conclusion, we have established reverse genetics to generate a qualified reassortant H5N2 vaccine virus for further development.
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
Abstract Influenza A viruses, as causative agents of seasonal epidemics and periodic worldwide pandemics, cause enormous mortality loss globally. The PR8 strain cultured in chicken eggs is widely used for scientific research and the production of influenza vaccines. Here, based on Cryo-electron Tomography (CET), we analyzed the morphological and structural characteristics of the influenza virus PR8 strain at different pHs. We found that a large number of defective virions were propagated in embryonated eggs. By comparing virions with/without the matrix layer, it was revealed that the matrix layer played an essenti...
Source: Biochemical and Biophysical Research communications - Category: Biochemistry Authors: Tags: Biochem Biophys Res Commun Source Type: research
ConclusionBased on high seroprevalence of antibodies against H1N1 virus during pandemic, vaccination of general population is not recommended. However, high-risk groups and HCWs need to be protected with flu vaccine. There is a need to encourage HCWs for accepting vaccination.
Source: Medical Journal Armed Forces India - Category: General Medicine Source Type: research
The high genetic variability of influenza A viruses poses a continual challenge to seasonal and pandemic vaccine development, leaving antiviral drugs as the first line of defence against antigenically different strains or new subtypes. As resistance against drugs targeting viral proteins emerges rapidly, we assessed the antiviral activity of already approved drugs that target cellular proteins involved in the viral life cycle and were orally bioavailable. Out of 15 candidate compounds, 4 were able to inhibit infection by ten- to hundredfold without causing toxicity, in vitro. Two of the drugs, dextromethorphan and ketotife...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
(University of Michigan) A universal flu vaccine that could prevent a potential influenza pandemic has been a holy grail for epidemiologists around the world ever since the first flu vaccines were developed in 1938.
Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news
Publication date: Available online 23 May 2019Source: BiologicalsAuthor(s): Kathryn Edwards, Germaine Hanquet, Steve Black, Emmanuel Mignot, Christopher Jankosky, Tom Shimabukuro, Elizabeth Miller, Hanna Nohynek, Pieter NeelsAbstractA group of scientific and public health experts and key stakeholders convened to discuss the state of knowledge on the relationship between adjuvanted monovalent inactivated 2009 influenza A H1N1 vaccines used during the 2009 influenza pandemic and narcolepsy. There was consensus that an increased risk of narcolepsy was consistently observed after Pandemrix (AS03-adjuvanted) vaccine, but simila...
Source: Biologicals - Category: Biology Source Type: research
(Taylor&Francis Group) The most severe pandemic in recent history, killing some 50 million people worldwide, the Spanish influenza, may have emerged up to two years earlier than previously believed. And, according to a new and influential study, its early manifestation was ignored at the time as a 'minor infection.'
Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news
Abstract A group of scientific and public health experts and key stakeholders convened to discuss the state of knowledge on the relationship between adjuvanted monovalent inactivated 2009 influenza A H1N1 vaccines used during the 2009 influenza pandemic and narcolepsy. There was consensus that an increased risk of narcolepsy was consistently observed after Pandemrix (AS03-adjuvanted) vaccine, but similar associations following Arepanrix (AS03-adjuvanted) or Focetria (MF59-adjuvanted) vaccines were not observed. Whether the differences are due to vaccine composition or other factors such as the timing of large-scal...
Source: Biologicals : Journal of the International Association of Biological Standardization - Category: Biotechnology Authors: Tags: Biologicals Source Type: research
More News: Children | Flu Pandemic | Health | Influenza | Influenza Vaccine | National Institutes of Health (NIH) | Pandemics | Sports Medicine | Study | Vaccines