Antihypercholesterolemic, antioxidative and anti-inflammatory potential of an extract of the plant Tabernaemontana divaricata in experimental rats fed an atherogenic diet

Publication date: Available online 30 March 2019Source: Biocatalysis and Agricultural BiotechnologyAuthor(s): Muniyandi Anbukkarasi, Mahalingam Sundararajan, Karuppasamy Venkadeswaran, Vasanthakumar Vasantha Ruban, Thiraviyam Anand, Pitchairaj GeraldineAbstractThe present study highlights the putative anti-atherogenic, antioxidative and anti-inflammatory potential of Tabernaemontana divaricata extract (ethanolic) in a Wistar rat model of experimental hypercholesterolemia. The rats were divided into Group I (control), Group II (atherogenic diet-fed, saline-treated) and Group III (atherogenic diet-fed, T. divaricata extract-treated [200 mg/kg/b.wt]). The levels of lipid profile parameters (total cholesterol, triglycerides, high-density, low-density and very low-density lipoprotein cholesterol and atherogenic index) and C-reactive protein (CRP) were investigated in serum samples. The levels of enzymatic and non-enzymatic antioxidants, malondialdehyde and nitric oxide (NO), and gene and protein expression levels of CRP, inducible nitric oxide synthase (iNOS) and tumor necrosis factor-α (TNF-α) and gene expression levels of interleukin-1β (IL-1β) were determined in liver tissue samples. Rats of Group II showed significantly heightened mean concentrations of CRP, and lower mean levels of lipid profile parameters, except high-density lipoprotein cholesterol, than control rats; Rats of Group II also exhibited significantly lower mean activities/levels of enzymatic and non-enzym...
Source: Biocatalysis and Agricultural Biotechnology - Category: Biotechnology Source Type: research