Vision Impairment in CKD Patients: Epidemiology, Mechanisms, Differential Diagnoses, and Prevention
Publication date: Available online 28 March 2019Source: American Journal of Kidney DiseasesAuthor(s): Simon Nusinovici, Charumathi Sabanayagam, Boon Wee Teo, Gavin Siew Wei Tan, Tien Yin WongEyes and kidneys have numerous structural, developmental, physiologic, and pathogenic pathways in common, suggesting that many kidney and eye diseases may be interlinked. Studies suggest that the prevalence of eye diseases and vision impairment are higher among persons with end-stage kidney disease and earlier stages of chronic kidney disease (CKD) than in those without. Ocular morbidity in persons with CKD and end-stage kidney disease may be due to the following risk factors: (1) underlying conditions and risk factors for CKD such as diabetes or hypertension, (2) metabolic disorders associated with CKD, (3) uremia and anemia, and (4) CKD treatment. Among the chief eye diseases, diabetic retinopathy and age-related macular degeneration are most consistently associated with CKD. Further research for eye diseases such as glaucoma and cataract is needed to determine their relationships with CKD. Despite the high prevalence and burden of vision impairment among persons with CKD, eye screening in patients with CKD is not currently recommended as standard practice. This review suggests that patients with CKD should be encouraged to undergo a complete eye examination. Furthermore, physicians should be aware that patients undergoing dialysis may develop acute eye problems such as acute ...
Authors: Xie Z, Chang C, Huang G, Zhou Z Abstract Type 1 diabetes (T1D) is an autoimmune disease caused by the interaction between genetic alterations and environmental factors. More than 60 susceptible genes or loci of T1D have been identified. Among them, HLA regions are reported to contribute about 50% of genetic susceptibility in Caucasians. There are many environmental factors involved in the pathogenesis of T1D. Environmental factors may change the expression of genes through epigenetic mechanisms, thus inducing individuals with susceptible genes to develop T1D; however, the underlying mechanisms remain ...
Conditions: Sickle Cell Disease; Sickle Cell Anemia Intervention: Drug: Voxelotor Sponsor: Global Blood Therapeutics Not yet recruiting
Condition: Foot Ulcer, Diabetic Intervention: Other: No intervention Sponsors: Podimetrics, Inc.; American Association of Diabetes Educators Enrolling by invitation
Condition: End Stage Renal Disease Interventions: Diagnostic Test: Venography; Diagnostic Test: Intravascular ultrasound (IVUS); Other: Image processing Sponsor: Boston Medical Center Not yet recruiting
Publication date: Available online 23 May 2020Source: EXPLOREAuthor(s): Erika Fayina Marie
Abstract More recent evidences are supportive of air pollution exposure on diabetes risk, including worsening of whole-body insulin sensitivity, enhancement of hepatic lipogenesis and nonalcoholic fatty liver disease after fine particulate matter (PM2.5) exposure. Therefore, we aimed to explore the lipidomics to get a comprehensive insight about ambient real-world PM2.5 exposure on lipid metabolism in blood and liver. After ambient PM2.5 exposure for 6 months, excess triglyceride accumulation in the liver was observed. Remarkable metabolic alterations including neutral lipids, glycerophospholipids and sphingolipid...
Publication date: Available online 23 May 2020Source: Neuroscience LettersAuthor(s): Chanan Meydan, Nurcan Üçeyler, Hermona Soreq
ConclusionTechnologies that evolve to include the characteristics described here will deliver more effective tools for patients, providers, payers, and policymakers and give patients control over sharing their data with those who need it in real time.