Knockdown of GRHL2 inhibited proliferation and induced apoptosis of colorectal cancer by suppressing the PI3K/Akt pathway.

In conclusion, GRHL2 acted as an oncoprotein through regulating cell proliferation and apoptosis in CRC cells. The PI3K/Akt pathway was closely involved in the effects of GRHL2. Therefore, GRHL2 might be a therapeutic target for the CRC treatment. PMID: 30917932 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/30917932?dopt=Abstract

Source: Gene - March 23, 2019 Category: Genetics & Stem Cells Authors: Hu F, He Z, Sun C, Rong D Tags: Gene Source Type: research