Genetic variants in RPA1 associated with the response to oxaliplatin-based chemotherapy in colorectal cancer

ConclusionsOur findings demonstrate an association between rs5030740 and the DCR and PFS of colorectal cancer patients.RPA1 functions as a putative oncogene in tumorigenesis by reducing sensitivity to oxaliplatin and could serve as a potential prognostic biomarker in colorectal cancer.
Source: Journal of Gastroenterology - Category: Gastroenterology Source Type: research