The neonatal treatment with clomipramina decreases sexual motivation and increases estrogen receptors expression in the septum of male rats: Effects of the apomorphine

Publication date: Available online 22 March 2019Source: Pharmacology Biochemistry and BehaviorAuthor(s): Tania Molina-Jiménez, Martín Jiménez-Tlapa, Malinalli Brianza-Padilla, Rossana Citlali Zepeda, Marisela Hernández-González, Herlinda Bonilla-JaimeAbstractAdministering clomipramine during the early days of life induced several behavioral and neurochemical alterations in adult male rats, which resemble major depression disorder. The alterations affected sexual performance, which is considered a reward-seeking behavior regulated by the dopaminergic system. Given that estrogen receptors are expressed in different areas of the brain involved in regulating reproductive behavior, motivation and mood, the objective of this study was to analyze the effect of apomorphine (a non-selective dopamine agonist) on sexual incentive motivation in rats exposed to clomipramine (CMI) in the neonatal period. In addition, it evaluated the expression of mRNA ERα and ERβ in the nucleus accumbens (NAcc) and septum of CMI rats. We found that only a few rats subjected to neonatal CMI treatment performed mounts, intromissions and ejaculations. Also, those rats spent less time exploring the sexual incentive zone and had lower preference scores; though this effect was reverted by administering 0.1 mg/kg of apomorphine. Finally, the CMI rats presented higher levels of mRNA ERα and ERβ, though only in the septum. These data indicate that neonatal...
Source: Pharmacology Biochemistry and Behavior - Category: Biochemistry Source Type: research

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CONCLUSIONS: Results suggest that the CES-D is a valid screening instrument for depressive disorders in military samples with a history of mTBI. PMID: 31017474 [PubMed - as supplied by publisher]
Source: Brain Injury - Category: Neurology Tags: Brain Inj Source Type: research
CONCLUSIONS: AMS predicts post-mTBI depressive symptoms both in the acute and chronic mTBI phases whereas LOC is a more sensitive predictor of post-concussive symptoms in the acute mTBI period. PMID: 31017017 [PubMed - as supplied by publisher]
Source: Brain Injury - Category: Neurology Tags: Brain Inj Source Type: research
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Source: Substance Use and Misuse - Category: Addiction Tags: Subst Use Misuse Source Type: research
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Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Young Adults Source Type: news
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Source: SafetyLit - Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
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Source: SafetyLit - Category: International Medicine & Public Health Tags: Ergonomics, Human Factors, Anthropometrics, Physiology Source Type: news
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Source: SafetyLit - Category: International Medicine & Public Health Tags: Research Methods, Surveillance and Codes, Models Source Type: news
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Source: SafetyLit - Category: International Medicine & Public Health Tags: Suicide and Self-Harm Source Type: news
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Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
Publication date: Available online 25 April 2019Source: Social Science &MedicineAuthor(s): Florian Arendt, Sebastian Scherr, Josh Pasek, Patrick E. Jamieson, Daniel RomerAbstractRationaleThe Netflix show 13 Reasons Why (2017) aroused widespread concern regarding potential contagious effects of its graphic depiction of an adolescent girl’s suicide and the events that led to her death.ObjectiveTo explore the effects of the second season of the show in 2018.MethodWe recruited a sample of young adults (ages 18–29; N = 729) with access to Netflix who completed surveys shortly before and one month after the relea...
Source: Social Science and Medicine - Category: Psychiatry & Psychology Source Type: research
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