(249) Modulators of Burn Injury-Related Pain in Mice: The Search for Modulators in the Transition from Acute to Chronic Pain

Acute pain is prevalent following burn injury and can transition to chronic pain in over 50% of patients. Prolonged acute pain is an important component that leads to chronic pain. Our research investigates burn injury-related pain and searches for risk factors that influence acute-to-chronic pain transitions. The present work tests whether dietary intervention, genetic background or pre-injury stress affects thermal and mechanical hypersensitivity associated with 2 ° burn of the mouse hindpaw. Under Avertin anesthesia, (200 µL/10g body weight), the paw of the mouse was placed on a metal block with a surface temperature of 65°C for 15 seconds.
Source: The Journal of Pain - Category: Materials Science Authors: Source Type: research