(383) Loss of Gnb5 in Sensory Neurons Leads to Decreased Nociceptive but not Pruriceptive Stimuli in Mice

Pain and itch are two somatosensory modalities whose pathologic manifestations cause immense suffering and health burden to millions of people worldwide. Mu-opioid ligands and analogs have been the mainstream therapy against pain, but due to their significant side effects there is an urgent need to have a deeper understanding of the signaling of opioid receptors and to identify newer drug targets which could help improve treatment for these pathologies. G β5 is a divergent member of the Gβ subunits of heterotrimeric G proteins which are unique in binding the Gγ like domain present in the R7- RGS proteins.

Source: The Journal of Pain - March 21, 2019 Category: Materials Science Authors: M. Pandey, J. Zhang, P. Adikaram, N. Lue, C. Kittock, C. Chen, W. Simonds Tags: Molecular and Cellular Biology (with CE) Source Type: research