The FDA Just Approved the First Drug for Postpartum Depression

The Food and Drug Administration approved the first drug specifically for the treatment of postpartum depression Tuesday. The drug, which is administered via an intravenous drip, reportedly works within 48 hours, providing near immediate relief to women experiencing symptoms, according to the New York Times. Postpartum depression has historically been treated with counseling or general antidepressants, which can take weeks to kick in or may not work at all. The newly-approved drug, brexanolone, will be marketed as Zulresso. The treatment will be offered only as an in-patient option at certified medical centers because it can cause sudden loss of consciousness, according to an F.D.A. press release. A pill version of the treatment could make the drug more widely accessible, and is currently undergoing clinical trials, according to the Times. Zulresso might cost up to $34,000 per patient, excluding the costs associated with several days stay in a medical center. Insurance companies are currently evaluating Zulresso, but Sage Therapeutics, the manufacturer, told the Times that it expects insurers to cover the treatment. The F.D.A. approved the new treatment after clinical studies showed that patients who received Zulresso have less depressive symptoms than patients given a placebo infusion. Read More: Cardi B Discusses Challenges After Giving Birth Brexanolone is synthetic form of allopregnanolone, which is a hormone produced by progesterone in the brain that can help alleviate ...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Health Care onetime overnight Source Type: news

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Publication date: Available online 20 June 2019Source: NeuroscienceAuthor(s): Matteo Di Segni, Diego Andolina, Sebastian Luca D’Addario, Lucy Babicola, Donald Ielpo, Alessandra Luchetti, Tiziana Pascucci, Luisa Lo Iacono, Francesca R. D'Amato, Rossella VenturaAbstractAlterations in early environmental conditions that interfere with the creation of a stable mother-pup bond have been suggested to be a risk factor for the development of stress-related psychopathologies later in life. The long-lasting effects of early experiences are mediated by changes in various cerebral circuits, such as the corticolimbic system, whic...
Source: Neuroscience - Category: Neuroscience Source Type: research
CONCLUSIONS: Mothers with migraine are more likely to have a baby with colic, while fathers with migraine are not. Further research is needed to determine the mechanisms underlying these findings. In the meantime, clinicians may wish to counsel parents with a maternal history of migraine about the increased possibility of having a colicky infant and provide resources and education about infant crying. PMID: 31222745 [PubMed - as supplied by publisher]
Source: Headache - Category: Neurology Authors: Tags: Headache Source Type: research
This week’s Psychology Around the Net covers ways you can be “good” at therapy (no joke), highlights an 11-year-old Montreal boy who created a video game to help kids understand mental health, how focusing on a few key habits can help keep you grounded when life gets hectic, recognizing postpartum depression in fathers, and more. Get to learning! Therapists Share 7 Ways You Can Be “Good” at Getting Therapy: No, this definitely is not about winning at therapy. You won’t find tips on how to make your therapist like you or trick your therapist into thinking you’re not as sad as you ac...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Psychology Around the Net anxiety esketamine goals habits Happiness Luke Toledo men and postpartum depression panic Spravato Therapy Video Games workplace Source Type: blogs
Abstract Epidemiological and clinical studies suggest that early-life stress (ELS) may lead to the development of mental disorders in adulthood. Maternal separation (MS) is a valid animal model of ELS that produces detrimental effects on brain and behavior of experimental animals. Positive environmental stimuli have been shown to counteract the behavioral deficits of ELS and enhance neuroplasticity. Recent data indicate that music may serve as a form of environmental enrichment in experimental animals. However, the underlying mechanisms through which musical enrichment exerts its effects are poorly understood. Mal...
Source: Behavioural Brain Research - Category: Neurology Authors: Tags: Behav Brain Res Source Type: research
Abstract In the neocortex, gap junctions are expressed at very early developmental stages, and they are involved in many processes such as neurogenesis, neuronal migration and synapse formation. Connexin43 (Cx43), a gap junction protein, has been found to be abundantly expressed in radial glial cells, excitatory neurons and astrocytes. Although accumulating evidence suggests that Cx43-mediated gap-junctional coupling between astrocytes plays an important role in the central nervous system, the function of Cx43 in early excitatory neurons remains elusive. To investigate the impact of Cx43 deficiency in excitatory n...
Source: Brain Research - Category: Neurology Authors: Tags: Brain Res Source Type: research
Abstract This randomized controlled trial was conducted on 80 Iranian pregnant women with unplanned pregnancy. The participants were randomly assigned to two groups of intervention and control. The intervention group received one to three sessions of individual counseling and six sessions of group counseling each week in six consecutive weeks, and the control group received routine care. The Edinburgh Postnatal Depression Scale and the Spielberger State-Trait Anxiety Inventory were completed by the participants before and 4 weeks after the intervention. There was no significant difference between groups in te...
Source: Community Mental Health Journal - Category: Psychiatry Authors: Tags: Community Ment Health J Source Type: research
I’ve been a mental health therapist for over 10 years and in the social work profession for more than 20. I have been pregnant 8 times, with 4 living children. I consider myself to be pretty self-aware, intelligent, and inquisitive. And yet… I had some form of perinatal mood and anxiety disorders (PMADs) with each of my pregnancies. I just didn’t know it. Oh, sure, I got sad and I got angry and with my older son, I couldn’t let myself fully bond to him until he was 9 months old, but I was fine, right? I even took medication, but that’s normal, right? I was introduced to PMADs last year when ...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Parenting Personal Pregnancy Women's Issues Birth trauma perinatal anxiety disorder perinatal mood disorder Postpartum Disorder Source Type: blogs
Objective The aim of the study was to investigate whether symptoms of depression or state anxiety changed the strength or nature of the association between hypertensive disorders of pregnancy (HDP) and gestational age at birth. Methods We conducted a secondary analysis of data from the All Our Families Cohort, a prospective pregnancy cohort study based in Calgary, Alberta, Canada. Self-reported depressive symptoms and state anxiety were assessed between 3 and 5 months of gestation, and obstetrical information, including diagnosis of HDP, parity, type of delivery, and gestational age at birth, was retrieved from the ma...
Source: Psychosomatic Medicine - Category: Psychiatry & Psychology Tags: ORIGINAL ARTICLES Source Type: research
CONCLUSION: Awareness of postnatal depression appeared high. However, areas including anxiety, antenatal mental health, and men's mental health were less well-understood. There remains considerable scope, and a need for, continued awareness-raising around anxiety, mental health in pregnancy and men's mental health. PMID: 31148499 [PubMed - as supplied by publisher]
Source: The International Journal of Social Psychiatry - Category: Psychiatry Authors: Tags: Int J Soc Psychiatry Source Type: research
ConclusionIn this study, postpartum depressive and anxiety symptoms played an important role in shaping difficult infant temperament. Comorbidity between the two conditions warrants clinical attention and additional research, since it is related to maternal perception of difficult infant temperament. Psychological interventions are required, since these women may require assistance with emotional adaptation in the transition to motherhood.
Source: Sexual and Reproductive Healthcare - Category: Reproduction Medicine Source Type: research
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