Motional dynamics of single Patched1 molecules in cilia are controlled by Hedgehog and cholesterol [Cell Biology]
The Hedgehog-signaling pathway is an important target in cancer research and regenerative medicine; yet, on the cellular level, many steps are still poorly understood. Extensive studies of the bulk behavior of the key proteins in the pathway established that during signal transduction they dynamically localize in primary cilia, antenna-like solitary...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Lucien E. Weiss, Ljiljana Milenkovic, Joshua Yoon, Tim Stearns, W. E. Moerner Tags: PNAS Plus Source Type: research
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