FXR1 expression domain in Wilms tumor

Wilms tumor (WT) is the most common childhood kidney cancer globally. Our prior unbiased proteomic screen of WT disparities revealed increased expression of Fragile X-Related 1 (FXR1) in Kenyan specimens where survival is dismal. FXR1 is an RNA-binding protein that associates with poor outcomes in multiple adult cancers. The aim of this study therefore was to validate and characterize the FXR1 expression domain in WT.

Source: Journal of Pediatric Surgery - March 17, 2019 Category: Surgery Authors: Hannah M. Phelps, Janene M. Pierce, Andrew J. Murphy, Hernan Correa, Jun Qian, Pierre P. Massion, Harold N. Lovvorn Source Type: research