Proinflammatory Cytokines as Biomarkers for BOS, Death, or Retransplantation after Lung Transplantation

Chronic Lung Allograft Dysfunction (CLAD) is characterized by airway epithelial damage and fibrosis. The origin and initiation of fibrosis are poorly understood. We hypothesized that immune mediators in bronchoalveolar lavage (BAL) predict bronchiolitis obliterans syndrome (BOS), a form of CLAD, and poor survival. In a multi-center observational study, we investigated the role of proinflammatory cytokines as biomarkers for poor outcome after lung transplant (LTx).
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: 126 Source Type: research