Ablation of the ASCT2 (SLC1A5) gene encoding a neutral amino acid transporter reveals transporter plasticity and redundancy in cancer cells [Metabolism]

The neutral amino acid transporter solute carrier family 1 member 5 (SLC1A5 or ASCT2) is overexpressed in many cancers. To identify its roles in tumors, we employed 143B osteosarcoma cells and HCC1806 triple-negative breast cancer cells with or without ASCT2 deletion. ASCT2ko 143B cells grew well in standard culture media, but ASCT2 was required for optimal growth at

Source: Journal of Biological Chemistry - March 14, 2019 Category: Chemistry Authors: Angelika Broer, Gregory Gauthier–Coles, Farid Rahimi, Michelle van Geldermalsen, Dieter Dorsch, Ansgar Wegener, Jeff Holst, Stefan Broer Tags: Membrane Biology Source Type: research