Co-inhibitory T cell receptor KLRG1: human cancer expression and efficacy of neutralization in murine cancer models.

Conclusions: These studies provide the first evidence that inhibition of the KLRG1 pathway enhances immune control of cancer in murine models, and provide target validation for KLRG1 targeting of human cancer. The mechanism of efficacy of KLRG1 blockade in murine models remains to be determined. PMID: 30858925 [PubMed]
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research