Circulating Heme Oxygenase-1 and Complement Activation in Transplant-Associated Thrombotic Microangiopathy

Transplant-associated thrombotic microangiopathy (TA-TMA) is a severe complication in patients following hematopoietic stem cell transplantation (HSCT). Previous investigations suggest that multiple factors resulting in endothelial cell injury lead to the occurrence of TA-TMA. Specifically, the abnormity of complement system contributes to the development of TA-TMA. TA-TMA shares a similar clinical manifestation with thrombotic thrombocytopenic purpura (TTP) and atypical hemolytic uremic syndrome (aHUS), which is characteristic with microangiopathic hemolytic anemia, platelet consumption, fibrin deposition in the microcirculation, and, ultimately, end-organ injury [1].

Source: Biology of Blood and Marrow Transplantation - March 10, 2019 Category: Hematology Authors: Tingting Pan, Jiaqian Qi, Tao You, Shiyu Han, Liping Yang, Wenjing Miao, Depei Wu, Changgeng Ruan, Li Zhu, Yue Han Source Type: research