Simultaneous Determination of Glutamate and Calcium Ion in Rat Brain during Spreading Depression and Ischemia Processes

This study provided a simple and effective approach for in vivo analysis of two or more chemical substances.Graphical abstractA dual function microelectrode (DFME) biosensor was designed and developed for simultaneous determination of glutamate and Ca2+, and was successfully applied for real-time monitoring of glutamate and Ca2+ in live rat brain during spreading depression (SD) and ischemia processes.
Source: Chinese Journal of Analytical Chemistry - Category: Chemistry Source Type: research