Research Progress of C-reactive Protein Analysis
Publication date: September 2020Source: Chinese Journal of Analytical Chemistry, Volume 48, Issue 9Author(s): Ming-Qing TANG, Xu-Hua MAO, Yi-Xin-Yue GONG, Lin-Sen QING, Jing XIE (Source: Chinese Journal of Analytical Chemistry)
Source: Chinese Journal of Analytical Chemistry - September 4, 2020 Category: Chemistry Source Type: research

Progress and Application of Liquid Electrode Glow Discharge for Atomic Spectrometry
Publication date: September 2020Source: Chinese Journal of Analytical Chemistry, Volume 48, Issue 9Author(s): An-Qin LENG, Yao LIN, Li YONG, Cheng-Bin ZHENG (Source: Chinese Journal of Analytical Chemistry)
Source: Chinese Journal of Analytical Chemistry - September 4, 2020 Category: Chemistry Source Type: research

A Flexible Electrochemical Sensor Based on L-Arginine Modified Chemical Vapor Deposition Graphene Platform Electrode for Selective Determination of Xanthine
Publication date: September 2020Source: Chinese Journal of Analytical Chemistry, Volume 48, Issue 9Author(s): Zhi-Kun BAI, Yi-Tao ZHANG, She-Hong LI, Hong-Xia LUO (Source: Chinese Journal of Analytical Chemistry)
Source: Chinese Journal of Analytical Chemistry - September 4, 2020 Category: Chemistry Source Type: research

Metabolomic Study of Kidney Injury Induced by Antitubercular Drugs and Therapeutic Effect of Glutathione Based on Gas Chromatography-Mass Spectrometry
Publication date: September 2020Source: Chinese Journal of Analytical Chemistry, Volume 48, Issue 9Author(s): Lin-Xiu PENG, Tong XIE, Jin-Jun SHAN (Source: Chinese Journal of Analytical Chemistry)
Source: Chinese Journal of Analytical Chemistry - September 4, 2020 Category: Chemistry Source Type: research

Non-target Screening Analysis of Volatile Organic Compounds in Drinking Water by Headspace-solid Phase Microextraction Gas Chromatography-Mass Spectrometry
Publication date: September 2020Source: Chinese Journal of Analytical Chemistry, Volume 48, Issue 9Author(s): Ming-Yue YU, Xiao-Qiu YANG, Rong FAN, Yu-Kang ZHENG, Jian-Bo SHI, Qi ZHENG (Source: Chinese Journal of Analytical Chemistry)
Source: Chinese Journal of Analytical Chemistry - September 4, 2020 Category: Chemistry Source Type: research

Fullerene Functionalized Magnetic Molecularly Imprinted Polymer: Synthesis, Characterization and Application for Efficient Adsorption of Methylene Blue
Publication date: September 2020Source: Chinese Journal of Analytical Chemistry, Volume 48, Issue 9Author(s): Hai XU, Pan ZHANG, Shao-Yan ZHOU, Qiong JIA (Source: Chinese Journal of Analytical Chemistry)
Source: Chinese Journal of Analytical Chemistry - September 4, 2020 Category: Chemistry Source Type: research

Distribution and Transition of Stable Conformations in Unfolding of Bovine Insulin Induced by Urea and Guanidine Hydrochloride
Publication date: September 2020Source: Chinese Journal of Analytical Chemistry, Volume 48, Issue 9Author(s): Jia-Xin ZHANG, Ru-Xue ZHANG, Wen-Li LIU, Huan CHEN, Liu-Jiao BIAN (Source: Chinese Journal of Analytical Chemistry)
Source: Chinese Journal of Analytical Chemistry - September 4, 2020 Category: Chemistry Source Type: research

Recent Advances in Single Cell Analysis Methods Based on Mass Spectrometry
Publication date: August 2020Source: Chinese Journal of Analytical Chemistry, Volume 48, Issue 8Author(s): Ju-Duo WANG, Jia-Feng SONG, Chang LI, Xin-Hua DAI, Xiang FANG, Xiao-Yun GONG, Zi-Hong YE (Source: Chinese Journal of Analytical Chemistry)
Source: Chinese Journal of Analytical Chemistry - August 13, 2020 Category: Chemistry Source Type: research

Synthesis of PEGylated BaGdF5 Nanoparticles as Efficient CT/MRI Dual-modal Contrast Agents for Gastrointestinal Tract Imaging
Publication date: August 2020Source: Chinese Journal of Analytical Chemistry, Volume 48, Issue 8Author(s): Feng-Zhi CUI, Jian-Hua LIU, Yang LIU, Bi-Ying YUAN, Xue GONG, Qing-Hai YUAN, Ting-Ting GONG, Lei WANG (Source: Chinese Journal of Analytical Chemistry)
Source: Chinese Journal of Analytical Chemistry - August 13, 2020 Category: Chemistry Source Type: research

In Situ Specific Chromogenic and Fluorogenic Reaction for Straight forward and Dual-Modal Dopamine Detection
Publication date: August 2020Source: Chinese Journal of Analytical Chemistry, Volume 48, Issue 8Author(s): Jia-Hui ZHAO, Guo-Yong LIU, Shuang WANG, Sha-Sha LU, Jian SUN, Xiu-Rong YANG (Source: Chinese Journal of Analytical Chemistry)
Source: Chinese Journal of Analytical Chemistry - August 13, 2020 Category: Chemistry Source Type: research

Improving Quantitative Accuracy of Ammonia from Open-Path Fourier Transform Infrared Spectroscopy by Incorporating Actual Spectra into Synthetic Calibration Set of Partial Least Squares Regression
Publication date: August 2020Source: Chinese Journal of Analytical Chemistry, Volume 48, Issue 8Author(s): Qian-Wei SONG, Ming-Quan GUO, Li-Min SHAO (Source: Chinese Journal of Analytical Chemistry)
Source: Chinese Journal of Analytical Chemistry - August 13, 2020 Category: Chemistry Source Type: research

Selective Removal of Cu2+ Ion in Aqueous Solution by Poly (Acrylic Acid/Acrylamide) Hydrogel
Publication date: August 2020Source: Chinese Journal of Analytical Chemistry, Volume 48, Issue 8Author(s): Ling-Yun YU, Rui-Li LI, Hai-Lun WU, Shan-Fa ZHANG, Min-Wei CHAI, Xiao-Xue SHEN, Mei HONG, Hai LIN (Source: Chinese Journal of Analytical Chemistry)
Source: Chinese Journal of Analytical Chemistry - August 13, 2020 Category: Chemistry Source Type: research

Recent Progress on Tissue Analysis by Mass Spectrometry without Sample Pretreatment
Publication date: July 2020Source: Chinese Journal of Analytical Chemistry, Volume 48, Issue 7Author(s): Yu-Fen WANG, Hai-Yan LU, Hua ZHANG, Huan-Wen CHEN (Source: Chinese Journal of Analytical Chemistry)
Source: Chinese Journal of Analytical Chemistry - July 5, 2020 Category: Chemistry Source Type: research

Imaging of Cell Migration Mediated Exocytosis with Gold Nanoprobes
Publication date: July 2020Source: Chinese Journal of Analytical Chemistry, Volume 48, Issue 7Author(s): Xiao-Dong XIE, Min YIN, Qian LI, Nan CHEN (Source: Chinese Journal of Analytical Chemistry)
Source: Chinese Journal of Analytical Chemistry - July 5, 2020 Category: Chemistry Source Type: research

Accurate Determination and Characterization of Gold Nanoparticles Based on Single Particle-Inductively Coupled Plasma-Mass Spectrometry
Publication date: July 2020Source: Chinese Journal of Analytical Chemistry, Volume 48, Issue 7Author(s): Jing-Bo CHAO, Jing-Ru WANG, Jing-Qi ZHANG (Source: Chinese Journal of Analytical Chemistry)
Source: Chinese Journal of Analytical Chemistry - July 5, 2020 Category: Chemistry Source Type: research

Stimuli-responsive Polymers-based Two-dimensional Photonic Crystals Biosensors
Publication date: July 2020Source: Chinese Journal of Analytical Chemistry, Volume 48, Issue 7Author(s): Chun-Guo CUI, Ai-Mei YOU, Kai-Yao SHI, RUI LIU, Yu-Yuan LU, Qiang ZHANG (Source: Chinese Journal of Analytical Chemistry)
Source: Chinese Journal of Analytical Chemistry - July 5, 2020 Category: Chemistry Source Type: research

Phenothiazine and BN-doped AIE Probes Integrated Fluorescence Sensor Array for Detection and Discrimination of Nitro Explosives
Publication date: July 2020Source: Chinese Journal of Analytical Chemistry, Volume 48, Issue 7Author(s): Cheng CHENG, Muhammad-Azhar-Hayat NAWAZ, Chao-Yi LIU, Sohail-Anjum SHAHZAD, Hui-Peng ZHOU, Cong YU, Xing JIN (Source: Chinese Journal of Analytical Chemistry)
Source: Chinese Journal of Analytical Chemistry - July 5, 2020 Category: Chemistry Source Type: research

Progress in Analysis of Tau Protein
Publication date: June 2020Source: Chinese Journal of Analytical Chemistry, Volume 48, Issue 6Author(s): Lin-Yu LI, Xiao-Ying WANG (Source: Chinese Journal of Analytical Chemistry)
Source: Chinese Journal of Analytical Chemistry - June 6, 2020 Category: Chemistry Source Type: research

Paper-supported Co-culture System for Investigation of Exosomes Mediated Interactions between Breast Cancer Cells and Lung Fibroblasts
Publication date: June 2020Source: Chinese Journal of Analytical Chemistry, Volume 48, Issue 6Author(s): Zhun LIN, Xiao CHEN, Dong-Guo LIN, Da-Yu LIU (Source: Chinese Journal of Analytical Chemistry)
Source: Chinese Journal of Analytical Chemistry - June 6, 2020 Category: Chemistry Source Type: research

Determination of Volatile Metabolites in Microcystis Aeruginosa Using Headspace-Solid Phase Microextraction Arrow Combined with Gas Chromatography-Mass Spectrometry
Publication date: June 2020Source: Chinese Journal of Analytical Chemistry, Volume 48, Issue 6Author(s): Rui-Peng YU, Li-Ping WANG, Chen-Kai ZHAO, Sheng-Fang WU, Qi-Jun SONG (Source: Chinese Journal of Analytical Chemistry)
Source: Chinese Journal of Analytical Chemistry - June 6, 2020 Category: Chemistry Source Type: research

Determination of Ultra-Low Level Plutonium Isotopes in Large Volume Environmental Water Samples
Publication date: June 2020Source: Chinese Journal of Analytical Chemistry, Volume 48, Issue 6Author(s): Rui-Qin GAO, Xiao-Lin HOU, Lu-Yuan ZHANG, Wei-Chao ZHANG, Meng-Ting ZHANG (Source: Chinese Journal of Analytical Chemistry)
Source: Chinese Journal of Analytical Chemistry - June 6, 2020 Category: Chemistry Source Type: research

In Situ Carbon Stable isotope Analysis of Organic Carbon by Laser Ablation-Isotope Ratio Mass Spectrometry
Publication date: June 2020Source: Chinese Journal of Analytical Chemistry, Volume 48, Issue 6Author(s): Han ZHANG, Lai WEI, Xu LIAO, Jia-Ni WANG, Qiu-Yue SHI, Xian ZHANG (Source: Chinese Journal of Analytical Chemistry)
Source: Chinese Journal of Analytical Chemistry - June 6, 2020 Category: Chemistry Source Type: research

Detection of Secretion of Exosomes from Individual Cell in Real-Time by Multifunctional Nanoelectrode-Nanopore Nanopipettes
Publication date: June 2020Source: Chinese Journal of Analytical Chemistry, Volume 48, Issue 6Author(s): Wen-Nan FENG, Jin HE, Si-Ying LI, Dan YANG, Hong-Na LI, Guo-Cheng YANG, Qiang FU, Yu-Ping SHAN (Source: Chinese Journal of Analytical Chemistry)
Source: Chinese Journal of Analytical Chemistry - June 6, 2020 Category: Chemistry Source Type: research

Development of Aptamer Screening against Proteins and Its Applications
Publication date: May 2020Source: Chinese Journal of Analytical Chemistry, Volume 48, Issue 5Author(s): Li-Ping ZHAO, Ge YANG, Xiao-Min ZHANG, Feng QU (Source: Chinese Journal of Analytical Chemistry)
Source: Chinese Journal of Analytical Chemistry - May 14, 2020 Category: Chemistry Source Type: research

Research Advances of Aptamers Selection for Small Molecule Targets
Publication date: May 2020Source: Chinese Journal of Analytical Chemistry, Volume 48, Issue 5Author(s): Zi-Jian WANG, Er-Ning CHEN, Ge YANG, Xin-Ying ZHAO, Feng QU (Source: Chinese Journal of Analytical Chemistry)
Source: Chinese Journal of Analytical Chemistry - May 14, 2020 Category: Chemistry Source Type: research

Capillary Electrophoresis Involving in High Efficiency Screening for Aptamers
Publication date: May 2020Source: Chinese Journal of Analytical Chemistry, Volume 48, Issue 5Author(s): Chao ZHU, Xin-Ying ZHAO, Ge YANG, Feng QU (Source: Chinese Journal of Analytical Chemistry)
Source: Chinese Journal of Analytical Chemistry - May 14, 2020 Category: Chemistry Source Type: research

Progress of Aptamer Screening Techniques Based on Microfluidic Chips
Publication date: May 2020Source: Chinese Journal of Analytical Chemistry, Volume 48, Issue 5Author(s): Hao JIANG, Xue-Fei LV, Ke-Xin ZHAO (Source: Chinese Journal of Analytical Chemistry)
Source: Chinese Journal of Analytical Chemistry - May 14, 2020 Category: Chemistry Source Type: research

Screening of Aptamer for Human IgG Fc Fragment by Capillary Electrophoresis-Systematic Evolution of Ligands by Exponential Enrichment
Publication date: May 2020Source: Chinese Journal of Analytical Chemistry, Volume 48, Issue 5Author(s): Ge YANG, Shi-Miao HAN, Li-Ping ZHAO, Chao ZHU, Yuan-Yu HUANG, Feng QU (Source: Chinese Journal of Analytical Chemistry)
Source: Chinese Journal of Analytical Chemistry - May 14, 2020 Category: Chemistry Source Type: research

Investigation of Library Input on Aptamers Selection Efficiency Using Capillary Electrophoresis
Publication date: May 2020Source: Chinese Journal of Analytical Chemistry, Volume 48, Issue 5Author(s): Lin-Sen LI, Chao ZHU, Yi ZHAO, Ge YANG, Feng QU (Source: Chinese Journal of Analytical Chemistry)
Source: Chinese Journal of Analytical Chemistry - May 14, 2020 Category: Chemistry Source Type: research

Selection and Identification of Common Aptamers against Both Vibrio Harveyi and Vibrio Alginolyticus
Publication date: May 2020Source: Chinese Journal of Analytical Chemistry, Volume 48, Issue 5Author(s): Hui-Min LIU, Ju-Min HAO, Jing XU, Qing-Pi YAN, Han GAO, Jiang ZHENG (Source: Chinese Journal of Analytical Chemistry)
Source: Chinese Journal of Analytical Chemistry - May 14, 2020 Category: Chemistry Source Type: research

Screening Aptamer of Apo-transferrin via Capillary Electrophoresis-Systematic Evolution of Ligands by Exponential Enrichment and Environmental Factors Analysis
Publication date: May 2020Source: Chinese Journal of Analytical Chemistry, Volume 48, Issue 5Author(s): Ge YANG, Yi ZHAO, Shi-Miao HAN, Chao ZHU, Yuan-Yu HUANG, Feng QU (Source: Chinese Journal of Analytical Chemistry)
Source: Chinese Journal of Analytical Chemistry - May 14, 2020 Category: Chemistry Source Type: research

Screening of Aptamer for Breast Cancer Biomarker Calreticulin and Its Application to Detection of Serum and Recognition of Breast Cancer Cell
Publication date: May 2020Source: Chinese Journal of Analytical Chemistry, Volume 48, Issue 5Author(s): Miao SUN, Ge YANG, Yi ZHAO, Feng QU (Source: Chinese Journal of Analytical Chemistry)
Source: Chinese Journal of Analytical Chemistry - May 14, 2020 Category: Chemistry Source Type: research

Selection and Characterization of Aptamers for Specific Detection of Iridovirus Disease in Cultured Hybrid Grouper (Epinephelus Fuscoguttatus♀ × E. Lanceolatus♂)
Publication date: May 2020Source: Chinese Journal of Analytical Chemistry, Volume 48, Issue 5Author(s): Qing YU, Ming-Zhu LIU, He-He XIAO, Yi YI, Hao CHENG, Dedi-Fazriansyah Putra, Si-Qiao LI, Peng-Fei LI (Source: Chinese Journal of Analytical Chemistry)
Source: Chinese Journal of Analytical Chemistry - May 14, 2020 Category: Chemistry Source Type: research

Determination of Aflatoxin B1 in Lotus Seed by High Performance Liquid Chromatography with Aptamer Affinity Column for Purification and Enrichment
Publication date: May 2020Source: Chinese Journal of Analytical Chemistry, Volume 48, Issue 5Author(s): Ying ZHAO, Nan WANG, Hua-Long GAO, Zi-Xuan GUO, An-Xiang LU, Xiao-Jun GUO, Jing-Hua LU, Yun-Xia LUAN (Source: Chinese Journal of Analytical Chemistry)
Source: Chinese Journal of Analytical Chemistry - May 14, 2020 Category: Chemistry Source Type: research

An Aptameric Biolayer Interferometric Assay for Detection of Recombinant Human Erythropoietin-α
Publication date: May 2020Source: Chinese Journal of Analytical Chemistry, Volume 48, Issue 5Author(s): Xiao-Qin HE, Li LUO, Lei GUO, Jian-Wei XIE (Source: Chinese Journal of Analytical Chemistry)
Source: Chinese Journal of Analytical Chemistry - May 14, 2020 Category: Chemistry Source Type: research

Applications of Click Chemistry Reaction for Proteomics Analysis
Publication date: April 2020Source: Chinese Journal of Analytical Chemistry, Volume 48, Issue 4Author(s): Fang-Ling ZHAN, Si-Yu GAO, Yuan-Dong XIE, Jin-Ming ZHANG, Yi LI, Ning LIU (Source: Chinese Journal of Analytical Chemistry)
Source: Chinese Journal of Analytical Chemistry - April 4, 2020 Category: Chemistry Source Type: research

Influence of Inorganic Gases on Formation and Chemical Composition of Monoaromatic Hydrocarbons Secondary Organic Aerosol
Publication date: April 2020Source: Chinese Journal of Analytical Chemistry, Volume 48, Issue 4Author(s): Jun XU, Ming-Qiang HUANG (Source: Chinese Journal of Analytical Chemistry)
Source: Chinese Journal of Analytical Chemistry - April 4, 2020 Category: Chemistry Source Type: research

Detection of Chemical Compositions of Ultrafine Nanoparticles by a Vacuum Ultraviolet Photoionization Nucleation Aerosol Mass Spectrometer
Publication date: April 2020Source: Chinese Journal of Analytical Chemistry, Volume 48, Issue 4Author(s): Zuo-Ying WEN, Xiao-Feng TANG, Tao WANG, Xue-Jun GU, Wei-Jun ZHANG (Source: Chinese Journal of Analytical Chemistry)
Source: Chinese Journal of Analytical Chemistry - April 4, 2020 Category: Chemistry Source Type: research

Electrochemical Sensors for Simultaneous Determination of Small Biomolecules By 3D Layered Hollow Honeycomb-like Ni-NiO@CPVP Modified Glassy Carbon Electrode
Publication date: April 2020Source: Chinese Journal of Analytical Chemistry, Volume 48, Issue 4Author(s): Zi-Yuan SONG, Ying MA, Jian-Shan YE (Source: Chinese Journal of Analytical Chemistry)
Source: Chinese Journal of Analytical Chemistry - April 4, 2020 Category: Chemistry Source Type: research

Facile Determination of Anesthetic Drug Propofol Based on Electrochemiluminescence Quenching
Publication date: April 2020Source: Chinese Journal of Analytical Chemistry, Volume 48, Issue 4Author(s): Xiu-Shuang FAN, Xiao-Di FAN, Xue-Mei FENG, Chen-Chen LI, Chu-Yao BI, Jing LI, Jian-Yuan YIN, Yan-Chao HAN (Source: Chinese Journal of Analytical Chemistry)
Source: Chinese Journal of Analytical Chemistry - April 4, 2020 Category: Chemistry Source Type: research

In-Gel Probing Polymorphic Structures of G-Quadruplexes Derived from c-Myc Promoter
Publication date: March 2020Source: Chinese Journal of Analytical Chemistry, Volume 48, Issue 3Author(s): Tian-Jun CHANG, Li WU, Wen-Xiu BIAN, Tao BING, Tong-Qian ZHAO, Di-Hua SHANGGUAN (Source: Chinese Journal of Analytical Chemistry)
Source: Chinese Journal of Analytical Chemistry - March 10, 2020 Category: Chemistry Source Type: research

Cu2+-mediated Fluorescence Switching of Graphene Quantum Dots for Highly Selective Detection of Glutathione
Publication date: March 2020Source: Chinese Journal of Analytical Chemistry, Volume 48, Issue 3Author(s): Xin-Yu LI, Qiang ZHANG, Ni WANG, Jia-Jun LIU, Jian WANG (Source: Chinese Journal of Analytical Chemistry)
Source: Chinese Journal of Analytical Chemistry - March 10, 2020 Category: Chemistry Source Type: research

Molecularly Imprinted Photoelectrochemical Sensor Based on AgBiS2/Bi2S3 for Determination of Propoxur
Publication date: March 2020Source: Chinese Journal of Analytical Chemistry, Volume 48, Issue 3Author(s): Xiao-Xue SHI, Xiu-Qi LI, Xiao-Ping WEI, Jian-Ping LI (Source: Chinese Journal of Analytical Chemistry)
Source: Chinese Journal of Analytical Chemistry - March 10, 2020 Category: Chemistry Source Type: research

A Novel Electrochemical Sensor Based on Au-Dy2(WO4)3 Nanocomposites for Simultaneous Determination of Uric Acid and Nitrite
Publication date: March 2020Source: Chinese Journal of Analytical Chemistry, Volume 48, Issue 3Author(s): Yu-Mei ZHANG, Hai-Ping HUANG, Liang XU (Source: Chinese Journal of Analytical Chemistry)
Source: Chinese Journal of Analytical Chemistry - March 10, 2020 Category: Chemistry Source Type: research

Cu(II) Metal-Organic Framework Encapsulated in Carbon Paste Electrode for High-Performance Non-Enzymatic Glucose Sensing
Publication date: March 2020Source: Chinese Journal of Analytical Chemistry, Volume 48, Issue 3Author(s): Lan WU, Zhi-Wei LU, Ying MA, Jun-Jun ZHANG, Guang-Quan MO, Hai-Jun DU, Jian-Shan YE (Source: Chinese Journal of Analytical Chemistry)
Source: Chinese Journal of Analytical Chemistry - March 10, 2020 Category: Chemistry Source Type: research

Progress on Applications of G-quadruplex in Biochemical Analysis
This article introduces the classification and function of G-quadruplex, and its application in small molecule, protein, enzyme, metal ion, target DNA/RNA detection, cell imaging and cancer therapy. (Source: Chinese Journal of Analytical Chemistry)
Source: Chinese Journal of Analytical Chemistry - February 7, 2020 Category: Chemistry Source Type: research

Advances in Fabrication of Polydiacetylene Vesicles and Their Applications in Medical Detection
Publication date: February 2020Source: Chinese Journal of Analytical Chemistry, Volume 48, Issue 2Author(s): Yu-Jia HAO, Guang-Ming ZHUAbstractPolydiacetylenes (PDAs) have received increasing attention as smart materials owing to their unique optical and electronic properties. PDAs are most commonly synthesized as self-assembled bilayer vesicles via 1,4 addition polymerization. Vesicles are often perceived as closely mimicking the cell membrane, thus functioning as convenient biomimetic platforms. PDAs undergo colorimetric and fluorescent transition in response to external stimuli. Therefore, PDA vesicles can be used in th...
Source: Chinese Journal of Analytical Chemistry - February 7, 2020 Category: Chemistry Source Type: research

Study on Drug Resistance to Tumor Cell in Oxygen Gradient and Co-culture Microfluidic Chip
Publication date: February 2020Source: Chinese Journal of Analytical Chemistry, Volume 48, Issue 2Author(s): Wei SUN, Yu-Qing CHEN, Ming-Fang WANG, Yue-Rong WANG, Min ZHANG, Hong-Yang ZHANG, Ping HUAbstractThe tumor microenvironment is a complex system that plays a vital role in proliferation, invasion and metastasis. In this work, an oxygen concentration gradient microfluidic chip was designed to construct an in vitro model of tumor hypoxic microenvironment. The microfluidic chip was composed of two parts, one was a serpentine-shape channel for hypoxia reagent mix to generate oxygen gradient, the other part contained thre...
Source: Chinese Journal of Analytical Chemistry - February 7, 2020 Category: Chemistry Source Type: research

Label-free Quantitative Proteomics for Investigation of Signaling Pathways of GATA6 Regulating Trastuzumab Resistance in Gastric Cancer Cells
In this study, Crispr/Cas9 was employed to establish a GATA6 knock-out cell line (NCI N87R/GATA6). The signaling pathways regulated by GATA6 and related to trastuzumab resistance were investigated based on label-free quantitative proteomics combined with bioinformatics. The extracted proteins were alkylated, and digested using filter aided sample preparation (FASP), and the peptides were separated via high performance liquid chromatography (HPLC) and thereafter quantified by liquid chromatography coupled with tandem mass spectroscopy (LC-MS/MS). Differentially expressed proteins were screened by fold change and student's t...
Source: Chinese Journal of Analytical Chemistry - February 7, 2020 Category: Chemistry Source Type: research

Construction of Protein-mediated Copper Sulfide Bonded Mesoporous Silica Nanoparticles Vector for Chemo-photothermal Synergistic Therapy of Cancer
Publication date: February 2020Source: Chinese Journal of Analytical Chemistry, Volume 48, Issue 2Author(s): Ruo-Xi HE, Qi WANG, Bei LI, Jing JIA, Wen-Jing LU, Shao-Min SHUANGAbstractBovine serum albumin-mediated copper sulfide nanocomplex (BSA/CuS) was modified on the mesoporous silica (MSN) loaded with chemotherapeutic drug doxorubicin (DOX) by amide bond to prepare a new drug carrier MSN-DOX@BSA/CuS. The disulfide bond of blocking agent BSA broke down after the redox reaction with glutathione, resulting in the MSN pore exposure and release of DOX. As a photothermal reagent, CuS could convert light energy into heat for p...
Source: Chinese Journal of Analytical Chemistry - February 7, 2020 Category: Chemistry Source Type: research