Immunostimulatory cytokine and doxorubicin co-loaded Nanovesicles for Cancer Immunochemotherapy

Publication date: Available online 2 March 2019Source: Nanomedicine: Nanotechnology, Biology and MedicineAuthor(s): Tingting Wu, Qi Qiao, Xianya Qin, Dan Zhang, Zhiping ZhangAbstractTaking advantages of drug delivery system, immunostimulatory and chemotherapeutic agents with different physiochemical properties can be co-delivered to realize synergistic antitumor effect. Here the immunostimulatory cytokine interleukin-2 (IL-2) was firstly adsorbed in doxorubicin (DOX) loaded nanovesicles (NV-DOXIL-2) with high encapsulation efficiency by a facile solvent free method. After intravenous injection to melanoma bearing mice, NV-DOXIL-2 can accumulate in tumor and remarkably suppress tumor growth with negligible systemic toxicity. To extend the comprehensive application of this strategy, interferon-γ (IFN-γ) was further introduced to the combinatorial system to develop the cytokine cocktails adsorbed NVs. This kind of NVs can significantly inhibit the primary tumor growth and lung metastasis of triple-negative breast cancer. With exploration of underlying mechanism, the cytokine cocktails adsorbed NVs can facilitate maturation of dendritic cells, promote the infiltration and activation of CD8+ T lymphocytes and natural killer cells, increase the recruitment of CD45+ immune cells and Ly6G+ neutrophils.Graphical AbstractImmunostimulatory cytokine cocktails adsorbed nanovesicles were obtained by a facile solvent free method with high encapsulation efficiency for combinational immunoc...

Source: Nanomedicine: Nanotechnology, Biology and Medicine - March 4, 2019 Category: Nanotechnology Source Type: research