A retrospective study (2001 –2017) of acute and chronic morbidity and mortality associated with Staphylococcus aureus bacteraemia in a tertiary neonatal intensive care unit

ConclusionsPreterm and low birth weight infants were at highest risk of SAB. Only a small proportion of affected children had long-term clinical sequelae on follow-up. The high rate of recurrence and breakthrough bacteraemia suggests that early implementation of a targeted anti-staphylococcal antimicrobial regimen may be of particular benefit.
Source: Irish Journal of Medical Science - Category: General Medicine Source Type: research

Related Links:

A library of 14 nontoxic diterpenoid-like compounds (CC50> 70 µM on HepG2 human liver cells) was screened against Mycobacterium smegmatis, Staphylococcus aureus and Escherichia coli to determine antimicrobial activity. Some compounds with a phenethyl alcohol core substituted with a β-cyclocitral derivative demonstrated anti-mycobacterial activity, with the most active being compound 1 (MIC = 23.4 mg/L, IC50 = 0.6 mg/L). Lower activity was exhibited against S. aureus, while no activity was displayed against E. coli. Low cytotoxicity was confirmed on HepG2 cells and newly derived for RAW 264.7 murine macrophage...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
This study aimed to define the impact of DM on long-term mortality in IE patients. A total of 412 patients with definite IE from February 1999 to June 2012 were enrolled in this observational study and divided into 2 groups: group 1, patients with DM (n = 72) and group 2, patients without DM (n = 340). The overall in-hospital mortality rate for both groups combined was 20.2% and was higher in group 1 than in group 2 (41.7% vs. 16.5%, p < 0.01). Compared to patients without DM, patients with DM were older and associated with higher incidence of chronic diseases, less drug abuse, higher creatinine levels, and increase...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
Two 1,4-benzoquinone derivatives, found in the venom of the scorpion Diplocentrus melici following exposure to air, have been isolated, characterized, synthesized, and assessed for antimicrobial activities. Initially a white, viscous liquid, the extracted venom colors within minutes under ambient conditions. From this colored mixture, two compounds, one red, the other...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Tags: Physical Sciences Source Type: research
Discussion Transplantation is not a common problem for primary care physicians but when a child’s disease has progressed to end-stage organ failure, transplantation can be the only treatment available. While the primary care provider usually is not involved in the daily management of patients before, during and after transplantation, they can be involved in many areas. These can include providing appropriate primary and acute care, ordering and obtaining necessary medical tests, medications and equipment, assisting with medical insurance, providing medical history and records to consultants, translating medical infor...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
Background: Use of Echocardiography in suspected endocarditis is well established in SAB. On the contrary, GNB endocarditis is rare (1 –2%) but echocardiography requests are not uncommon suggesting a potential knowledge gap in its optimal utilisation for endocarditis.
Source: Heart, Lung and Circulation - Category: Cardiology Authors: Tags: 258 Source Type: research
Journal Name: Clinical Chemistry and Laboratory Medicine (CCLM) Issue: Ahead of print
Source: Clinical Chemistry and Laboratory Medicine - Category: Laboratory Medicine Source Type: research
Publication date: Available online 22 June 2019Source: Molecular and Cellular ProbesAuthor(s): Nasim Hajighahramani, Mahboobeh Eslami, Manica Negahdaripour, Mohammad Bagher Ghoshoon, Ali Dehshahri, Nasrollah Erfani, Reza Heidari, Ahmad Gholami, Navid Nezafat, Younes GhasemiGraphical abstract
Source: Molecular and Cellular Probes - Category: Molecular Biology Source Type: research
Authors: Ishaq R, Ansari MS, Rakha BA, Qadeer S, Akhter S Abstract Aim: The present study was designed to evaluate enrofloxacin (EN), a fluoroquinolone broad-spectrum antibacterial drug for use in cryopreservation of Zebu bull semen. Materials and Methods: Semen was collected from three Zebu bulls of the Sahiwal breed (Bos indicus) for 3 weeks (replicates) for each experiment. Experiment I: semen samples were cultured for isolation of bacteria and in vitro sensitivity tests against streptomycin, penicillin, and EN. Proteus spp., Pseudomonas aeruginosa, Staphylococcus aureus, and Escherichia coli were isolated. P. a...
Source: Biopreservation and Biobanking - Category: Biomedical Science Tags: Biopreserv Biobank Source Type: research
Publication date: November 2019Source: Materials Science and Engineering: C, Volume 104Author(s): Adam Kubiak, Katarzyna Siwińska-Ciesielczyk, Joanna Goscianska, Anna Dobrowolska, Elżbieta Gabała, Katarzyna Czaczyk, Teofil JesionowskiAbstractBinary oxide systems containing TiO2 and CuO were synthesized using hydrothermal treatment and shown to have enhanced antibacterial properties. A detailed investigation was made of the effect of the molar ratio of components (TiO2:CuO = 7:3, 5:5, 3:7, 1:9) on the physicochemical parameters and antibacterial activity. Analysis of morphology (SEM, TEM and HRTEM) confirmed the pres...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
Publication date: Available online 21 June 2019Source: BurnsAuthor(s): Chathuranga C. De Silva, Nikita Israni, Anand Zanwar, Amit Jagtap, Porakrit Leophairatana, Jeffrey T. Koberstein, Shanta M. ModakAbstractThe delivery of antimicrobial agents to surface wounds has been shown to be of central importance to the wound healing process. In this work, we prepared film forming wound care formulations containing 3 polymers (FTP) that provide broad-spectrum antimicrobial protection for prolonged periods. FTP formulations comprises of a smart gel matrix comprising of pH-degradable and temperature responsive polyacetals (smart poly...
Source: Burns - Category: Dermatology Source Type: research
More News: Biomedical Science | Children | General Medicine | Intensive Care | Ireland Health | Laboratory Medicine | Perinatology & Neonatology | Science | Skin | Staphylococcus Aureus | Study