Phenotypic Characterization of Malignant Progenitor Cells in Patients with Idiopathic Myelofibrosis

ConclusionThese data indicate that IL-3Rαhigh CD34+ cells from IM enriched for the malignant progenitor cells and IL-3Rα/CD123 may be a potential biomarker and therapeutic target for IM. Our findings will be further validated in future studies with a larger sample size and serial transplant in murine models.
Source: Hematology Oncology and Stem Cell Therapy - Category: Cancer & Oncology Source Type: research