Adeno-associated virus 9-mediated RNA interference targeting SOCS3 alleviates diastolic heart failure in rats.

CONCLUSIONS: SOCS3 gene silencing by AAV9-SOCS3 siRNA administration in a DHF rat model significantly reduced myocardial fibrosis and the inflammatory response and improved heart function. Therefore, this treatment is a potential therapeutic method for treating DHF. PMID: 30763670 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/30763670?dopt=Abstract

Source: Gene - February 11, 2019 Category: Genetics & Stem Cells Authors: Gao J, Guo Y, Chen Y, Zhou J, Liu Y, Su P Tags: Gene Source Type: research