The non-thyroidal illness syndrome in critically ill children: prognostic value and impact of nutritional management.

CONCLUSION: In critically ill children, the peripheral inactivation of thyroid-hormone, characterized by the decrease in T3/rT3, which is further accentuated by low/no macronutrient intake, appears beneficial. In contrast, the central component of NTI attributable to suppressed TSH, evidenced by the decrease in T4, seems to be a harmful response to critical illness. Whether treating the central component with TRH infusion in PICU is beneficial requires further investigation. PMID: 30760183 [PubMed - as supplied by publisher]
Source: Thyroid : official journal of the American Thyroid Association - Category: Endocrinology Tags: Thyroid Source Type: research