Evaluation of 11C-LSN3172176 as a novel PET tracer for imaging M1 muscarinic acetylcholine receptors in non-human primates.

Conclusion: 11C-LSN3172176 exhibits excellent in vivo binding and imaging characteristics in non-human primates and appears to be the first appropriate radiotracer for PET imaging of human M1 AChR.
PMID: 30733324 [PubMed - as supplied by publisher]

Source: Methods of Information in Medicine - February 7, 2019 Category: Information Technology Authors: Nabulsi NB, Holden D, Zheng MQ, Bois F, Lin SF, Najafzadeh S, Gao H, Ropchan J, Lara-Jaime T, Labaree D, Shirali A, Slieker LJ, Jesudason CD, Barth VN, Navarro A, Kant N, Carson RE, Huang H Tags: J Nucl Med Source Type: research