rh-IFN-α Attenuates Neuroinflammation and Improves Neurological Function by Inhibiting NF-κB through JAK1-STAT1/TRAF3 Pathway in an Experimental GMH Rat Model

In conclusion, our findings demonstrated that rh-IFN-α treatment attenuated neuroinflammation, neurological deficits and hydrocephalus formation through inhibiting microglial activation after GMH, which might be mediated by IFNAR/JAK1-STAT1/TRAF3/NF-κB signaling pathway. Rh-IFN-α may be a promising therapeutic agent to attenuate brain injury via its anti-inflammatory effect.
Source: Brain, Behavior, and Immunity - Category: Neurology Source Type: research