Exercise Versus Pharmacological Interventions for Reducing Visceral Adiposity and Improving Health Outcomes

Obesity is considered to be a pandemic that has increased exponentially during the last decades, and yet it still remains largely underdiagnosed and undertreated.1 Findings from large cohort studies suggest that by 2025, global obesity prevalence will reach 18% in men and surpass 21% in women.2 Currently, worldwide overweight and obesity prevalence may be as high as 36.9% and 38.0% in men and women, respectively,3 being even higher in developed countries.3 Obesity predisposes to diverse disorders, including insulin resistance, metabolic syndrome, cardiovascular disease (CVD), and type 2 diabetes (T2D).
Source: Mayo Clinic Proceedings - Category: Internal Medicine Authors: Tags: Editorial Source Type: research

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ConclusionThe present SR provides state-of-the-art information about the use of metabolomics as an approach to understanding the dynamics of metabolic processes involved in human obesity and emphasizes metabolic signatures related to obesity phenotypes.
Source: Metabolomics - Category: Biology Source Type: research
Conclusions: Bariatric surgery appears to be capable of partially reversing the obesity-related epigenome. The identification of potential epigenetic biomarkers predictive for the success of bariatric surgery may open new doors to personalized therapy for severe obesity. Introduction Obesity is currently a huge healthcare problem, worldwide, and is a risk factor for several diseases such as type 2 diabetes (T2D), cardiovascular disease and cancer (1). As the prevalence of obesity reaches pandemic proportions, this metabolic disease is estimated to become the biggest cause of mortality in the near future (2). In fact,...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
Abstract Obesity is a worldwide pandemic in adults as well as children and adds greatly to health care costs through its association with type 2 diabetes, metabolic syndrome, cardiovascular disease, and cancers. The prevailing medical view of obesity is that it results from a simple imbalance between caloric intake and energy expenditure. However, numerous other factors are important in the etiology of obesity. The obesogen hypothesis proposes that environmental chemicals termed obesogens promote obesity by acting to increase adipocyte commitment, differentiation, and size by altering metabolic set points or alter...
Source: Pharmacological Reviews - Category: Drugs & Pharmacology Authors: Tags: Annu Rev Pharmacol Toxicol Source Type: research
ConclusionsThe results of this pilot study show that RYGB fundamentally alters microRNA expression in circulation with a time-dependent progressive departure in profile from the preoperative baseline and indicate that microRNAs are potentially novel biomarkers for the benefits of bariatric surgery.
Source: BMC Obesity - Category: Eating Disorders & Weight Management Source Type: research
(University of Montreal) Obesity and its negative impacts on health -- including metabolic syndrome, type 2 diabetes mellitus and cardiovascular complications -- are a global pandemic. Researchers at Maisonneuve-Rosemont Hospital in Montreal shed light on a safeguard mechanism.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
In conclusion, documentation is important, a critical part of advocacy and the development process at the larger scale. It isn't just words, but rather a vital structural flow of information from one part of the larger community to another, necessary to sustain progress in any complex field. We would all do well to remember this - and to see that building this documentation is an activity in which we can all pitch in to help. Evidence Suggests that, at Least in Earlier Stages, Alzheimer's Disease Blocks Rather than Destroys Memories https://www.fightaging.org/archives/2017/07/evidence-suggests-that-at-least-in-ea...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Conclusions Body fat distribution can be considered as a parameter in assessing adipokine imbalance. Central adiposity is a better measure of adipokine imbalance than BMI. Abdominal obesity in diabetics correlates with altered levels of adipocytokines indicating its importance in diabetic individuals.
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - Category: Endocrinology Source Type: research
Publication date: Available online 10 June 2016 Source:Molecular Metabolism Author(s): Torsten P.M. Scheithauer, Geesje M. Dallinga-Thie, Willem M. de Vos, Max Nieuwdorp, Daniël H. van Raalte Background The twin pandemics of obesity and type 2 diabetes (T2D) are a global challenge for health care systems. Changes in the environment, behavior, diet, and lifestyle during the last decades are considered the major causes. A Western diet, which is rich in saturated fat and simple sugars, may lead to changes in gut microbial composition and physiology, which have recently been linked to the development of metabolic d...
Source: Molecular Metabolism - Category: Endocrinology Source Type: research
Obesity is a rapidly growing pandemic. Scope of pharmacotherapy and bariatric surgery in managing obesity is ever rising. The role of minimally invasive techniques to achieve preoperative weight loss and improve postbariatric surgery outcomes is an area of new interest. The initial experience with endobarrier devices in achieving weight loss among obese subjects has shown promising results. In addition, the impact of these interventions on comorbidities commonly associated with obesity like diabetes mellitus type 2 and hyperlipidemia has further expanded their potential for use in future. In this review article, we have su...
Source: Journal of Clinical Gastroenterology - Category: Gastroenterology Tags: Clinical Reviews Source Type: research
Abstract Non-alcoholic fatty liver disease (NAFLD) is closely associated with diabetes, obesity and the metabolic syndrome and leads to considerable vascular and liver-related burden of disease. Whilst regarded as a sequelae of the modern Western sedentary, food-rich lifestyle, NAFLD was actually noted in Japan nearly 50 years ago and its epidemiology, associated with affluence and increased food consumption, are well-documented. In fact, Asian populations appear to have an increased susceptibility to NAFLD, partly owing to visceral adipose body composition differences and changing cultural effects. Whilst th...
Source: Current Hepatitis Reports - Category: Infectious Diseases Source Type: research
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