Major gene expression events of Plasmodium falciparum pathogenicity

Purpose: Plasmodium falciparum is the most fatal strain cause severe infection and death especially in children and pregnant women. 80% of malaria deaths in Africa occur in pregnant women and children below 5 years. Cerebral malaria (CM) in children is the most severe neurological complication of infection with Plasmodium falciparum and it is a leading cause of childhood neuro-disability in surviving children who have an increased risk of epilepsy with behavioral difficulties. Pregnancy associated malaria (PAM) is more severe and more fatal due to puerperal sepsis includes cerebral malaria, fever illness and mortality can occur from haemorrhage.
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: 21.153 Source Type: research