Reduced Intensity Vs Myeloablative Conditioning Regimen for Pediatric Therapy-Related Myelodysplastic Syndrome/Acute Myeloid Leukemia

Therapy-related myelodysplastic syndrome and acute myeloid leukemia (t-MDS/AML) are rare but well-recognized complications of cancer therapy. Allogeneic hematopoietic cell transplantation (HCT) with myeloablative conditioning (MAC) remains the mainstay of treatment but is associated with a high incidence of non-relapse mortality (NRM). Reduced intensity conditioning (RIC) may reduce NRM in these heavily pre-treated patients. The primary objective of this study was to compare outcomes following RIC and MAC regimens in patients receiving an allogeneic HCT.

Source: Biology of Blood and Marrow Transplantation - January 31, 2019 Category: Hematology Authors: Akshay Sharma, Russell J. Brooke, Neel S. Bhatt, Ying Li, Heather B. Allewelt, Joshua J. Bies, Jennifer E. Brondon, Nicholas J. Gloude, Erica S. Goeckerman, Katherine M. Harris, Richard H. Ho, Michelle Hudspeth, Jeffrey S. Huo, David A. Jacobsohn, Kimberl Tags: 17 Source Type: research