Myeloid Leukemia with Myelodysplasia-Related Changes Was Not a Prognostic Factor Under Allogenic Hematopoietic Stem Cell Transplantation

Acute myeloid leukemia with myelodysplasia-related changes (AML-MRC) is briefly defined as an AML which have multilineage dysplasia (MLD), a history of myelodysplastic syndrome (MDS) and/or an MDS-related cytogenetic abnormalities. Recent study showed that AML-MRC exhibits a worse clinical outcome than AML not otherwise specified (AML-NOS). Though allogenic hematopoietic stem cell transplantation (allo-SCT) is believed to improve the outcome of AML-MRC, few reports had referred to its benefit. The purpose of this study was to clarify the outcome and the prognostic factors of patients (pts) with AML-MRC who underwent allo-SCT.

Source: Biology of Blood and Marrow Transplantation - January 31, 2019 Category: Hematology Authors: Yoonha Lee, Tomoe Ichiki, Motohito Okabe, Yuka Kawaguchi, Marie Ohbiki, Masahide Osaki, Miyo Goto, Takahiko Sato, Hiroaki Araie, Tatsunori Goto, Takanobu Morishita, Yukiyasu Ozawa, Koichi Miyamura Tags: 154 Source Type: research