Effects of nicotine conditioning history on alcohol and methamphetamine self-administration in rats

ConclusionsIn female, but not male rats, an appetitive conditioning history with nicotine decreases methamphetamine, but not alcohol, self-administration. This dissociation suggests that the effects may be due to a specific increase in the reinforcing value of methamphetamine. This may have implications for better understanding the progression of drug use from nicotine to methamphetamine.
Source: Pharmacology Biochemistry and Behavior - Category: Biochemistry Source Type: research