Changes in motor function and brain cortex mitochondrial active oxygen species production in aged mice.
In this study, 3 and 17 months old male Swiss mice were used. Aged mice exhibited a significant reduction in motor performance and walking footprint pattern. Synaptosomes and mitochondrial fractions were isolated from mouse brain cortex. Active oxygen species and cardiolipin content were measured in both subcellular fractions. Synaptosomal acetylcholinesterase activity was measured in both animal age groups. Results showed that superoxide levels were 42.9% lower in synaptosomes from old mice as compared with young animals, while no changes were observed in non-synaptic mitochondria. Succinate-glutamate dependent H2O2 production rate was 27.5% decreased in non-synaptic mitochondria from aged mice. Cardiolipin content was 21% decreased in synaptosomes from 17-months old animals, while no changes were observed in non-synaptic mitochondria. Acetylcholinesterase activity decreased 16% in 17-months old mice, as compared with young animals. Age-related alterations in neuronal function could be associated with changes in active oxygen species at synapses, with parallel motor deficiencies. PMID: 30658119 [PubMed - as supplied by publisher]
Publication date: July 2019Source: Journal of Experimental Child Psychology, Volume 183Author(s): Caroline Surrey, Anett Kretschmer-Trendowicz, Mareike Altgassen, Rico FischerAbstractThe ability to use contextual cues to adjust cognitive control according to situational demands is a hallmark of flexible and adaptive behavior. We investigated the development of three different types of contextual control recruitment in children (9- and 12-year-olds) and young adults. First, we implemented a list-wide proportion congruence manipulation in which conflict trials were frequently/infrequently presented within a list of trials. S...
ConclusionsFindings suggest that self-harm behavior and psychiatric disorders are associated with increased ED utilization for subsequent chronic disease-related ED utilization. Chronic disease among adolescent psychiatric patients should be attended to, potentially involving new models of clinical follow-up care.
Publication date: May 2019Source: International Journal of Educational Development, Volume 67Author(s): Simone Datzberger, Marielle L.J. Le MatAbstractBy drawing on the case study of Uganda, we challenge common assumptions about education, gender, regional differences and political agency. Comparing findings from four different regions, we scrutinize whether and how educational institutions empower Ugandan youth to participate in society as active, informed, critical and responsible citizens. Theoretically, we focus on four different aspects of individual political agency that education can foster, namely: understanding of...
Human Development 2019;62:5 –13
Publication date: Available online 21 March 2019Source: Meat ScienceAuthor(s): Paula M. Conroy, Maurice G. O'Sullivan, Ruth M. Hamill, Joseph P. KerryAbstractThe study objectives were to determine assessors' (n = 256) preference for corned beef, produced with sequential reductions in NaCl concentrations and to determine if preference was affected by assessor age. The use of a salt replacer such as potassium lactate was also assessed. The youngest age cohort disliked samples containing the highest level of NaCl, whereas the oldest age cohort did not detect differences between samples. The most negatively perceived sampl...
Publication date: February 2019Source: Food Policy, Volume 83Author(s): Marc F. Bellemare, Mario Mazzocchi
Publication date: February 2019Source: Food Policy, Volume 83Author(s):
Conclusion: Immunization with the quadrivalent vaccine (HPV6, HPV11, HPV16, and HPV18) could potentially prevent genital warts caused by HPV infection.Intervirology
Conclusion: Acute TBI may suppress E2 and increase CORT in young women. OCs appeared to independently affect CORT and FSH responses. Future work is needed with a larger sample to characterize TBI effects on women's endogenous hormone response to injury and OC use's effects on post-TBI stress response and gonadal function, as well as secondary injury. PMID: 30891100 [PubMed - in process]
Authors: Behar A, Faiz E PMID: 30889970 [PubMed - as supplied by publisher]