Dual layer doI detector modules for a dedicated mouse brain PET/MRI.

Dual layer doI detector modules for a dedicated mouse brain PET/MRI. Phys Med Biol. 2019 Jan 17;: Authors: Parl C, Kolb A, Stricker-Shaver D, Pichler BJ Abstract The outcome of preclinical imaging studies are enhanced by simultaneous, high-resolution anatomical and molecular data, which advanced PET/MRI systems provide. Nevertheless, mapping of neuroreceptors and accurate quantification of PET tracer distribution in mouse brains is not trivial. The restricted spatial resolution and sensitivity in commercial animal PET systems limits the image quality and the quantification accuracy. We are currently developing a PET/MRI system dedicated for mouse brain studies. The PET system will offer system dimensions of approx. 30 mm in diameter and an axial length of more than 38 mm. 
 This work discusses two system geometries including their associated block detectors. Both configurations were based on a dual layer offset structure with small crystals sizes, in the order of 1×1×4/6 mm³, to provide discrete depth of interaction information. The detector for configuration "A" was based on a 4×4 silicon photomultiplier (SiPM) array attached to an optical diffusor, and a 12×12 as well as a 9×11 LSO crystal array, to achieve optimal system sensitivity. This configuration was evaluated by a double layer of 12×12 crystals. Configuration "B" was composed of three 2×2 SiPM arrays equipped with a 1 mm diffusor to read out an LSO stack of ...
Source: Physics in Medicine and Biology - Category: Physics Authors: Tags: Phys Med Biol Source Type: research