Carnitine Supplementation Attenuates Sunitinib-Induced Inhibition of AMP-Activated Protein Kinase Downstream Signals in Cardiac Tissues.

In conclusion, data from this study suggest that SUN inhibits AMPK downstream signaling with the consequent inhibition of mitochondrial transport of LCFA and energy production in cardiac tissues. Carnitine supplementation attenuates SUN-induced cardiotoxicity. PMID: 30644033 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/30644033?dopt=Abstract

Source: Cardiovascular Toxicology - January 14, 2019 Category: Cardiology Authors: Sayed-Ahmed MM, Alrufaiq BI, Alrikabi A, Abdullah ML, Hafez MM, Al-Shabanah OA Tags: Cardiovasc Toxicol Source Type: research