Microglia are effector cells of CD47-SIRP{alpha} antiphagocytic axis disruption against glioblastoma [Immunology and Inflammation]

Glioblastoma multiforme (GBM) is a highly aggressive malignant brain tumor with fatal outcome. Tumor-associated macrophages and microglia (TAMs) have been found to be major tumor-promoting immune cells in the tumor microenvironment. Hence, modulation and reeducation of tumor-associated macrophages and microglia in GBM is considered a promising antitumor strategy. Resident microglia...

Source: Proceedings of the National Academy of Sciences - January 15, 2019 Category: Science Authors: Gregor Hutter, Johanna Theruvath, Claus Moritz Graef, Michael Zhang, Matthew Kenneth Schoen, Eva Maria Manz, Mariko L. Bennett, Andrew Olson, Tej D. Azad, Rahul Sinha, Carmel Chan, Suzana Assad Kahn, Sharareh Gholamin, Christy Wilson, Gerald Grant, Joy He Tags: PNAS Plus Source Type: research