Researchers discover a hidden culprit in heart failure

(University of Alberta Faculty of Medicine&Dentistry) An international research team led by scientists at the University of Alberta have pinpointed a hidden culprit that leads to dilated cardiomyopathy--a dangerous condition that accounts for 20 per cent of all cases of heart failure--which opens the door to potential new treatments that could help counter the threat.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

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Patients with dilated cardiomyopathy (DCM) who achieved left ventricular reverse remodeling (LVRR) have a favorable prognosis, but it is still difficult to precisely predict LVRR in the clinical setting.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: (27) Source Type: research
Heart failure (HF) affects more than 6 million adults in the U.S and is associated with significant morbidity and mortality. The majority of HF patients suffer from either ischemic (ICM) or dilated (DCM) cardiomyopathy. Little is known about the genetic alterations in DCM or ICM patients. Therefore, our aim was to characterize differentially expressed genes in left ventricular tissue from DCM and ICM patients.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: (358) Source Type: research
Myocarditis is a known etiology of both acute fulminant heart failure and chronic dilated cardiomyopathy requiring heart transplantation. We sought to evaluate the long-term post-transplant outcomes of pts with myocarditis.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: (636) Source Type: research
We aim to evaluate clinical outcomes, echocardiographic changes, heart rate (HR) modifications and side effects in children with dilated cardiomyopathy (DCM) and chronic heart failure (HF) treated by high dosage of carvedilol.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: (1144) Source Type: research
Dilated cardiomyopathy (DCM) is a common cause of advanced heart failure (HF) in children and the risk of sudden death in DCM is not well defined although population-based studies have described risk factors like older age, familial DCM and lower fractional shortening. Myocardial fibrosis as assessed by late gadolinium enhancement (LGE) on 3-T cardiac magnetic resonance imaging (CMR) is well known to be associated with adverse events in DCM. We sought to assess the conditional survival (CS) of children and adolescents with DCM and advanced HF based on native T1 mapping (combined proton signal from myocytes and interstitium...
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: (301) Source Type: research
Contributors : Jiang Jianming ; Liao DanSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusDilated cardiomyopathy (DCM), defined by left ventricular (LV) enlargement associated with impaired cardiac performance, is a major cause of heart failure (HF). This results in a dilated, thin-walled left ventricle that fails to supply sufficient blood to the body. Truncating variants in TTN (TTNtv), coding for the largest structural protein in the sarcomere, contribute to the largest portion of familial and ambulatory DCM. The mechanisms for how TTNtv lead to cardiac dilation are unclear. Here, we...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
ConclusionsTreatment with BC 007 for β1‐AAB neutralization was safe, resulted in a long‐lasting reduction of β1‐AAB combined with improved cardiac function and prolonged the survival of DP with DCM. Using a natural large animal model of DCM considered superior to small animal models of immunization‐induced cardiomyopathy, com bined with a study design comparable with clinical trials, we believe that our results provide the basis for optimism that treatment with BC 007 might also be effective in human patients with DCM.
Source: ESC Heart Failure - Category: Cardiology Authors: Tags: Original Research Article Source Type: research
American Journal of Roentgenology, Ahead of Print.
Source: American Journal of Roentgenology - Category: Radiology Authors: Source Type: research
This study aimed to report the long‐term outcomes and clinical management following LVAD explantation.Methods and resultsAn analysis of the European Registry for Patients with Mechanical Circulatory Support was performed to identify all adult patients with myocardial recovery and successful explantation. Pre ‐implant characteristics were retrieved and compared with the non‐recovery patients. The follow‐up data after explantation were collected via a questionnaire. A Kaplan–Meier analysis for freedom of the composite endpoint of death, heart transplantation, LVAD reimplantion, or heart failure (H F) relapse wa...
Source: ESC Heart Failure - Category: Cardiology Authors: Tags: Original Research Article Source Type: research
AbstractThe majority of patients hospitalized for heart failure (HF) are admitted to internal medicine (IM) rather than to cardiology (CA) units, but to date few studies have analyzed the characteristics of these two populations. In this snapshot survey, we compared consecutive patients admitted for HF in six IM units vs. one non-intensive CA unit. During the 6-month survey period, 467 patients were enrolled (127 in CA, 27.2% vs. 340 in IM, 72.8%). IM patients were almost 10  years older (CA 75 ± 10, IM 82 ± 8 years;p 
Source: Internal and Emergency Medicine - Category: Emergency Medicine Source Type: research
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