Genomic Landscape of Pancreatic Adenocarcinoma in Younger vs Older Patients: Does Age Matter?

CONCLUSIONS: These exploratory analyses suggest that there may be somatic gene alterations within the population of early onset PDAC patients that involve unique cellular pathways compared with average onset PDAC. Former studies imply these cellular pathways may play a role in smoking-related PDAC carcinogenesis. Larger genomic datasets are warranted for future evaluation to extend these observations.
PMID: 30617137 [PubMed - as supplied by publisher]

Source: Clinical Cancer Research - January 7, 2019 Category: Cancer & Oncology Authors: Ben-Aharon I, Elkabets M, Pelossof R, Yu KH, Iacobuzio-Donahue CA, Leach SD, Lowery MA, Goodman KA, O'Reilly EM Tags: Clin Cancer Res Source Type: research