Clinical and research applications of magnetic resonance imaging in the study of CADASIL

Publication date: Available online 8 January 2019Source: Neuroscience LettersAuthor(s): Dorothee Schoemaker, Yakeel T. Quiroz, Heirangi Torrico-Teave, Joseph F. Arboleda-VelasquezAbstractCerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) is an inherited small vessel disease that leads to early cerebrovascular events and functional disability. It is the most common single-gene disorder leading to stroke. Magnetic resonance imaging (MRI) is a central component of the diagnosis and monitoring of CADASIL. Here we provide a descriptive review of the literature on three important aspects pertaining to the use of MRI in CADASIL. First, we review past research exploring MRI markers for this disease. Secondly, we describe results from studies investigating associations between neuroimaging abnormalities and neuropathology in CADASIL. Finally, we discuss previous findings relating MRI markers to clinical symptoms. This review thus provides a summary of the current state of knowledge regarding the use of MRI in CADASIL as well as suggestions for future research.
Source: Neuroscience Letters - Category: Neuroscience Source Type: research