Cyclosporine A protects podocytes via stabilization of cofilin-1 expression in the unphosphorylated state

In conclusion, the antiproteinuric effect of CsA is derived from the stabilization of the podocyte actin cytoskeleton by upregulating expression of cofilin-1, which was independent of its effect on synaptopodin.

Source: Experimental Biology and Medicine - July 28, 2014 Category: Research Authors: Li, X., Zhang, X., Li, X., Wang, X., Wang, S., Ding, J. Tags: Biochemistry & amp;amp; Molecular Biology Source Type: research