Bile cast nephropathy causing acute kidney injury in a patient with nonfulminant acute hepatitis A.

Bile cast nephropathy causing acute kidney injury in a patient with nonfulminant acute hepatitis A. Saudi J Kidney Dis Transpl. 2018 Nov-Dec;29(6):1498-1501 Authors: Ravi R, Suthar K, Murlidharan P, Lakshmi K, Balan S, Safeer M Abstract Hepatitis A is usually a benign self-limiting disease with few or no extrahepatic manifestations. Acute hepatitis A causing severe renal dysfunction is not very common, although described. Patients developing renal dysfunction post hepatitis A infection usually have prerenal acute kidney injury (AKI) or acute tubular necrosis due to vomiting, diarrhea, and poor fluid replacement. However, if renal dysfunction persists, other causes need to be evaluated. The term cholemic nephrosis or more specifically bile cast nephropathy has been described in the setting of cholestatic jaundice and decompensated liver failure where bilirubin levels reach above 20 mg/dL. Herein, we describe the clinical course of a patient who developed acute hepatitis A with severe liver dysfunction and subsequently AKI which persisted for six weeks. Renal biopsy showed the evidence of bile cast nephropathy. After six weeks of hemodialysis, urine output improved. He slowly recovered both hepatic and renal functions. PMID: 30588986 [PubMed - in process]
Source: Saudi Journal of Kidney Diseases and Transplantation - Category: Urology & Nephrology Authors: Tags: Saudi J Kidney Dis Transpl Source Type: research

Related Links:

Interface Biologics Inc (IBI) is a company from Toronto, Ontario, Canada that develops medtech and pharmaceutical materials. Their surface modification technology is called Endexo, which involves fluorine-based additives that migrate to a material&rs...
Source: Medgadget - Category: Medical Devices Authors: Tags: Anesthesiology Cardiology Critical Care Exclusive Materials Source Type: blogs
ConclusionsEhrlichia-induced HLH is a potential serious complication with relatively high occurrence rate; patients manifest severe disease with end-organ damage requiring longer hospital stay.
Source: Blood Cells, Molecules, and Diseases - Category: Hematology Source Type: research
Authors: Ceylan B, Yilmaz M, Beköz HS, Ramadan S, Ertan Akan G, Mert A Abstract Invasive aspergillosis is a severe infection that generally involves the lungs. Primary gastrointestinal aspergillosis is the least common form of invasive aspergillosis. A patient aged 65 years developed a febrile neutropenic episode following an autologous stem cell transplant for plasmacytoid variant diffuse large B-cell gastric non-Hodgkin's lymphoma. He had abdominal pain on the second day of the febrile neutropenic episode and ileus occurred on the sixth day. His general condition deteriorated despite broad spectrum antibioti...
Source: Infezioni in Medicina - Category: Infectious Diseases Tags: Infez Med Source Type: research
Authors: Bejjanki H, Koratala A Abstract Rothia mucilaginosa, previously known as Stomatococcus mucilaginosus, is a Gram-positive coccus that is a part of the oropharyngeal and upper respiratory tract microbiota. Although this organism is believed to be of low virulence, it is increasingly being recognized as an opportunistic pathogen mostly affecting immunocompromised hosts. In this article, we describe a case of Rothia mucilaginosa bacteremia in an immunocompromised heart transplant recipient with end-stage renal disease, who was getting maintenance hemodialysis via a tunneled catheter. To the best of our knowled...
Source: Infezioni in Medicina - Category: Infectious Diseases Tags: Infez Med Source Type: research
Authors: Gentile I, Pinchera B, Viceconte G, Crispo M, Simeone D, Scotto R, Zappulo E, Maraolo AE, Paladino F, Tortora R, Di Costanzo GG, Buonomo A, Borgia G Abstract Around 71 million people worldwide are chronically infected with hepatitis C. HCV prevalence among individuals born in the United States between 1945 and 1965 is estimated to be about 3%. In Italy, about 2% of the population is chronically infected with HCV. Since chronic HCV infection is often asymptomatic, many patients require access to medical care only in an advanced phase of the disease. The best strategy for bringing out hidden chronic HCV infe...
Source: Infezioni in Medicina - Category: Infectious Diseases Tags: Infez Med Source Type: research
CONCLUSION: Strategies to improve currently available diagnostic techniques, and studies dealing with vector control procedures and other operational tools and approaches are needed for better understanding of this health problem. PMID: 30882372 [PubMed - in process]
Source: Infezioni in Medicina - Category: Infectious Diseases Tags: Infez Med Source Type: research
IS, Bran EL Abstract Alopecia areata (AA) is a polygenic autoimmune disease. The immunosuppressant drugs taken by patients who undergo solid organ transplantation might therefore be useful in its control. The literature, however, contains conflicting information in this regard. This contribution describes seven patients with AA, all of whom had undergone solid organ transplantation and were receiving treatment with immunosuppressant drugs. Patterns were sought that might suggest whether the administration of these drugs was affecting the appearance, progress, or resolution of AA. Only seven out of 469 patients (in...
Source: Skinmed - Category: Dermatology Authors: Tags: Skinmed Source Type: research
ConclusionThe adoption of multiple strategies is required to improve the safety of the medication process in the adult oncology department. We argue that the availability of supportive leadership should be prioritized as it plays a crucial role in determining the effectiveness and efficiency of both staff education and communication.
Source: Saudi Pharmaceutical Journal - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 19 March 2019Source: Saudi Pharmaceutical JournalAuthor(s): Sarfaraz Ahmed, Adnan J. Alrehaily, Perwez Alam, Ali S. Alqahtani, Syed Hidayatullah, Md. Tabish Rehman, Ramzi A. Mothana, Syed Sadiq Abbas, M.U. Khan, Jamal M. Khalid, Nasir A. SiddiquiAbstractThe present study demonstrates the miquelianin or quercetin 3-O-glucuronide (compound 1) isolated from aerial parts of Euphorbia schimperi exhibited significant results for antioxidant and antidiabetic potential. The compound 1 along with kaempferol 3-O-glucuronide (compound 2) and quercetin 3-O- rhamnoside (compound 3) isolated from the s...
Source: Saudi Pharmaceutical Journal - Category: Drugs & Pharmacology Source Type: research
Tumor development may be suppressed by the immune system via elimination of cancer cells or via prevention of cancer cell outgrowth. The existence of CD8+CD69+CD103+ tissue resident memory T cells (TRM) and their known role in immune surveillance led Park and colleagues to investigate whether this cell population mediated immunity to epidermis-derived melanoma. Using a mouse model of transplantable melanoma, these investigators demonstrated that tissue-resident TRM established a dynamic melanoma-immune equilibrium in the epidermis, suppressing macroscopic tumor development.
Source: Journal of Investigative Dermatology - Category: Dermatology Tags: Editorial Source Type: research
More News: Bile | Bilirubin | Dialysis | Hemodialysis | Hepatitis | Hepatitis A | Jaundice | Kidney Transplant | Kidney Transplantation | Liver | Liver Transplant | Middle East Health | Saudi Arabia Health | Transplants | Urology & Nephrology