S‐allyl cysteine activates the Nrf2‐dependent antioxidant response and protects neurons against ischemic injury in vitro and in vivo

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Source: Journal of Neurochemistry - Category: Neuroscience Authors: Tags: Original Article Source Type: research

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Conditions:   Stroke;   Atrial Fibrillation Intervention:   Sponsors:   Sarawak General Hospital;   Sarawak Heart Centre;   Ministry of Health, Malaysia Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Interv Neuroradiol. 2021 Oct 19:15910199211041487. doi: 10.1177/15910199211041487. Online ahead of print.ABSTRACTINTRODUCTION: The optimal anaesthesia approach for endovascular treatment (EVT) in acute ischaemic stroke is currently unknown. In stroke due to medium vessel occlusions (MeVO), the occluded vessels are particularly small and more difficult to access, especially in restless or uncooperative patients. In these patients, general anaesthesia (GA) may be preferred by physicians to prevent complications due to patient movement. We investigated physicians' approaches to anaesthesia during EVT for MeVO stroke.METHODS: ...
Source: Interventional Neuroradiology - Category: Radiology Authors: Source Type: research
ConclusionmCTA tissue maps can be used to reliably detect MeVO stroke and predict tissue fate.
Source: Neuroradiology - Category: Radiology Source Type: research
ConclusionRI was an independent risk factor for poor 3-month neurologic outcomes and survival probability after MT in patients with acute vertebrobasilar stroke.
Source: Neuroradiology - Category: Radiology Source Type: research
Stroke induces disorder of gut microbiota, however, whether this disorder differs according to stroke severity and its role in the evolution and outcome of stroke is currently unknown. Here we explored the composition and structure of fecal microbiome based on 68 acute ischemic stroke patients presenting with minor symptoms (admission National Institute of Health Stroke Scale (NIHSS) ≤ 3) and 67 patients with non-minor stroke (admission NIHSS 4-34) using high-throughput Illumina sequencing of the 16S rRNA. There was no significant difference in α-diversity indices, but the principal coordinate analysis of the micr...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
Conclusions: This genetic evidence supports causal effects of T2DM liability and HbA1c on a range of cardiovascular diseases, suggesting that improving glycaemic control could reduce cardiovascular risk in a general population, with greatest benefit in individuals with diabetes.
Source: Genes - Category: Genetics & Stem Cells Authors: Tags: Communication Source Type: research
We describe four cases of mitochondrial strokes to highlight the considerable overlap that exists with other neurological disorders, including viral and autoimmune encephalitis, ischemic stroke, and central nervous system (CNS) vasculitis, and discuss the clinical, laboratory, and imaging features that can help distinguish MELAS from these differential diagnoses.
Source: Genes - Category: Genetics & Stem Cells Authors: Tags: Article Source Type: research
Protein C deficiency (PCD) is a rare inherited thrombophilia with high morbidity and mortality. Protein C plays an important role in the coagulation cascade by inactivating factors V and VIII, which then decreases thrombin production. In the absence of protein C, these pro-coagulant factors proceed unchecked, causing a hypercoagulable state. PCD may manifest with early and severe clinical complications, including purpura fulminans, disseminated intravascular coagulation, vitreal vein thrombosis resulting in blindness, and arterial ischemic stroke [1].
Source: Thrombosis Research - Category: Hematology Authors: Tags: Full Length Article Source Type: research
Alva Health, a medtech startup based in Connecticut, is developing a wristband that can detect the signs of stroke and promptly alert the wearer and/or healthcare staff. The technology is intended for those at high risk of stroke, such as stroke surv...
Source: Medgadget - Category: Medical Devices Authors: Tags: Exclusive Neurology Neurosurgery alvahealth stroke Source Type: blogs
Circulation. 2021 Oct 19;144(16):1272-1279. doi: 10.1161/CIRCULATIONAHA.121.054516. Epub 2021 Oct 18.ABSTRACTBACKGROUND: Substantial differences exist between United States counties with regards to premature (
Source: Circulation - Category: Cardiology Authors: Source Type: research
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