Inhibition of Protein Tyrosine Phosphatase 1B Protects Against Sevoflurane-induced Neurotoxicity mediated by ER stress in Developing Brain.

CONCLUSIONS: Our study shows PTP1B inhibition mitigates sevoflurane-induced neurodegeneration maybe mediated by ER stress in developing brain, and eventually improves cognitive function. This suggests PTP1B inhibition could represent a promising strategy to prevent sevoflurane-induced neurotoxicity. PMID: 30553844 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/30553844?dopt=Abstract

Source: Brain Research Bulletin - December 13, 2018 Category: Neurology Authors: Liu B, Ou G, Chen Y, Zhang J Tags: Brain Res Bull Source Type: research