Magnetofluorescent nanohybrid comprising polyglycerol grafted carbon dots and iron oxides: Colloidal synthesis and applications in cellular imaging and magnetically enhanced drug delivery.

Magnetofluorescent nanohybrid comprising polyglycerol grafted carbon dots and iron oxides: Colloidal synthesis and applications in cellular imaging and magnetically enhanced drug delivery. Colloids Surf B Biointerfaces. 2019 Jan 01;173:842-850 Authors: Wen Y, Xu M, Liu X, Jin X, Kang J, Xu D, Sang H, Gao P, Chen X, Zhao L Abstract Multifunctional nanohybrids are attracting increasing attention for potential biomedical applications such as bioimaging and drug delivery due to their combined advantages of individual components. However, challenges in the improvement of their synthesis and colloidal stability to facilitate practical biomedical applications still remain. In this work, we report an efficient synthetic approach to fabricate magnetofluorescent nanohybrid (IO-PG-CD) comprising fluorescent carbon dots (CDs) and magnetic iron oxide nanoparticles (IOs) through polyglycerol (PG) mediated covalent linkage in aqueous media. CDs and IOs are first grafted with PG layer, and then functionalized with carboxyl and amino groups, respectively. The resulting CD-PG-COOH and IO-PG-NH2 handled as simple chemical compounds are integrated through EDC/NHS crosslinking to obtain the desired IO-PG-CD nanohybrid. The unprecedented hydrophilicity of PG layer endows IO-PG-CD nanohybrid with excellent colloidal stability in various physiological media, facilitating biomedical applications in vitro and in vivo. IO-PG-CD nanohybrid exhibits low cytotoxi...
Source: Colloids and Surfaces - Category: Biotechnology Authors: Tags: Colloids Surf B Biointerfaces Source Type: research