Role and regulation of proapoptotic Bax in oral squamous cell carcinoma and drug resistance.
CONCLUSION: Hence, the Bax gene alteration and its deregulation through p53/Akt pathway are important for OSCC progression and drug resistance. Akt Inhibitor VIII and nimbolide synergistically induce Bax, and it is therefore beneficial for chemosensitizing cisplatin-resistant human OSCC.
PMID: 30549344 [PubMed - as supplied by publisher]
Source: Methods of Information in Medicine - Category: Information Technology Authors: Alam M, Kashyap T, Mishra P, Panda AK, Nagini S, Mishra R Tags: Head Neck Source Type: research
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