Mortality and Cancer Incidence in Carriers of Balanced Robertsonian Translocations: a National Cohort Study.

Mortality and Cancer Incidence in Carriers of Balanced Robertsonian Translocations: a National Cohort Study. Am J Epidemiol. 2018 Dec 07;: Authors: Minouk J S, Michael E J, Craig D H, Alan F W, United Kingdom Clinical Cytogenetics Group, Anthony J S Abstract A balanced Robertsonian translocation results from fusion of two acrocentric chromosomes. Carriers are phenotypically normal, and are often diagnosed because of recurrent miscarriages, infertility or aneuploid offspring. Mortality and site-specific cancer risks in carriers have not been prospectively investigated. We followed 1987 carriers diagnosed in Great Britain for deaths and cancer risk, over an average of 24.1 years. Standardised mortality (SMR) and incidence (SIR) ratios were calculated comparing the number of observed events against population rates. Overall mortality was raised for carriers diagnosed aged
Source: Am J Epidemiol - Category: Epidemiology Authors: Tags: Am J Epidemiol Source Type: research

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